Chemical Name: 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
Biological ActivityPotent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Interaction of Bruton's tyrosine kinase and protein kinase Cθ in platelets.
Crosby and Pool
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide].
Mahajan et al.
Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex.
Vassilev et al.
Citations for LFM-A13
The citations listed below are publications that use Tocris products. Selected citations for LFM-A13 include:
4 Citations: Showing 1 - 4
Balancing tonic and phasic inhibition in hypothalamic CRH-releasing hormone neurons.
Authors: Colmers and Bains
J Physiol 2018;596:1919
Erythropoietin Intensifies the Proapoptotic Activity of LFM-A13 in Cells and in a Mouse Model of Colorectal Cancer.
Authors: Tankiewicz-Kwedlo Et al.
Int J Mol Sci 2018;19
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
Authors: He Et al.
Essential role of Stat3 in PI3K-induced oncogenic transformation.
Authors: Hart Et al.
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