LFM-A13

  ( 2 citations )    
Product Datasheet
Catalog Number:1300
Chemical Name:2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
Product Details
Citations (2)
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Biological Activity
Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM.
Technical Data
  • M.Wt:
    360
  • Formula:
    C11H8Br2N2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    62004-35-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for LFM-A13 include:

2 Citations: Showing 1 - 2
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  1. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
    Authors: He Et al.
    Nature  2016;530:354
  2. Essential role of Stat3 in PI3K-induced oncogenic transformation.
    Authors: Hart Et al.
    Pain  2011;108:13247

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