8 results for "Brutons Tyrosine Kinase (BTK) Inhibitors" in Products
Brutons Tyrosine Kinase (BTK) Inhibitors
Bruton's Tyrosine Kinase (BTK) is member of the Tec family that is critically important for the growth, differentiation and activation of myeloid-, mast- and B-cells. BTK is activated firstly by membrane localization stimulated by PIP3 generation, and subsequently, by transphosphorylation of Tyr-551 by Src family kinases.
Activated BTK is involved in the phosphorylation of a number of signaling molecules involved in the PLCγ, JNK and p38 MAPK pathways, leading to Ca2+ mobilization, mRNA ...
Potent, selective BTK inhibitor
| Chemical Name: | 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide |
| Purity: | ≥98% |
Potent and selective BTK inhibitor
| Chemical Name: | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
| Purity: | ≥98% |
Potent and selective BTK Degrader (PROTAC®)
| Chemical Name: | 4-(1,1-Dimethylethyl)-N-[3-[6-[[4-[[4-[6-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetyl]amino]hexyl]-1-piperazinyl]carbonyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]benzamide |
| Purity: | ≥98% |
Potent ITK inhibitor; also inhibits BTK
| Chemical Name: | (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide |
| Purity: | ≥95% |
Potent BTK inhibitor
| Chemical Name: | 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% |
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
| Chemical Name: | 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride |
| Purity: | ≥98% |
Potent, reversible BTK inhibitor
| Chemical Name: | N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide |
| Purity: | ≥97% |
Potent BTK Degrader (PROTAC®)
| Chemical Name: | 3-[[4-[1-[[(3R)-1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-pyrrolidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-(1-piperidinyl)-2-pyrazinecarboxamide |
| Purity: | ≥98% |
