receptor modulator. Acts as a positive allosteric modulator of β
2 or β
3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA
receptor sensitization. Inhibits homomeric ρ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Loreclezole enhances apparent desensitisation of recombinant GABAA receptor currents.
Donnelly and Macdonald
Loreclezole inhibition of recombinant α1β1γ2L GABAA receptor single channel currents.
Fisher et al.
Loreclezole as a simple functional marker for homomeric ρ type GABAC receptors.
Thomet et al.
Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acidA receptors.
Smith et al.
The citations listed below are publications that use Tocris products. Selected citations for Loreclezole hydrochloride include:
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