Catalog Number: 1295
Chemical Name: (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride
Biological Activity
Subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric ρ1 GABAC receptors.
Technical Data
  • M.Wt:
    311
  • Formula:
    C10H6Cl3N3.HCl
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    117857-45-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Loreclezole enhances apparent desensitisation of recombinant GABAA receptor currents.
    Donnelly and Macdonald
    Neuropharmacology, 1996;35:1233
  2. Loreclezole inhibition of recombinant α1β1γ2L GABAA receptor single channel currents.
    Fisher et al.
    Neuropharmacology, 2000;39:235
  3. Loreclezole as a simple functional marker for homomeric ρ type GABAC receptors.
    Thomet et al.
    Eur.J.Pharmacol., 2000;408:R1
  4. Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acidA receptors.
    Smith et al.
    J.Pharmacol.Exp.Ther., 2004;311:601
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Loreclezole hydrochloride include:

1 Citations: Showing 1 - 1

  1. Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex.
    Authors: Kotak Et al.
    Mol Med 2008;18:2098

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