Chemical Name: (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride
Biological ActivityLoreclezole hydrochloride is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric ρ1 GABAC receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Loreclezole inhibition of recombinant α1β1γ2L GABAA receptor single channel currents.
Fisher et al.
Loreclezole enhances apparent desensitisation of recombinant GABAA receptor currents.
Donnelly and Macdonald
Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acidA receptors.
Smith et al.
Loreclezole as a simple functional marker for homomeric ρ type GABAC receptors.
Thomet et al.
Citations for Loreclezole hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Loreclezole hydrochloride include:
2 Citations: Showing 1 - 2
Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses.
Authors: Lemos Et al.
Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex.
Authors: Kotak Et al.
Mol Med 2008;18:2098
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Loreclezole hydrochloride
There are currently no reviews for this product. Be the first to review Loreclezole hydrochloride and earn rewards!
Have you used Loreclezole hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image