Catalog Number: 1530
Alternate Names: Mevinolin
Chemical Name: (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate
Biological Activity
Potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.
Technical Data
  • M.Wt:
    404.54
  • Formula:
    C24H36O5
  • Solubility:
    Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    75330-75-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery, biochemistry and biology of lovastatin.
    Alberts
    Am.J.Cardiol., 1988;62:10J
  2. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
    Alberts et al.
    Proc.Natl.Acad.Sci.U.S.A., 1980;77:3957
  3. Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis.
    Park et al.
    Anticancer Res., 1999;19:3133
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Lovastatin include:

4 Citations: Showing 1 - 4
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  1. Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.
    Authors: Saqcena Et al.
    Oncotarget 2015;14:2285
  2. The Effects of Targeted Deliveries of Lovastatin and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model.
    Authors: Ibrahim Et al.
    Int J Environ Res Public Health 2015;12:12958
  3. A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.
    Authors: Buchovecky Et al.
    Nat Genet 2013;45:1013
  4. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.
    Authors: Vainio Et al.
    J Neurosci 2011;2:1176

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