Potent, competitive inhibitor of HMG-CoA reductase (Ki
= 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro
and in vivo
. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro
. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo
following oral administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery, biochemistry and biology of lovastatin.
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alberts et al.
Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis.
Park et al.
Anticancer Res., 1999;19:3133
The citations listed below are publications that use Tocris products. Selected citations for Lovastatin include:
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