Lovastatin

Catalog # Availability Size / Price Qty
1530/10
1530/50
Lovastatin | CAS No. 75330-75-5 | HMG-CoA Reductase Inhibitors
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Description: Potent HMG-CoA reductase inhibitor
Alternative Names: Mevinolin

Chemical Name: (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate

Purity: ≥98%

Product Details
Citations (11)
Reviews (1)

Biological Activity

Potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Indirectly inhibits Rho-GTPase activity by depleting intracellular pool of isoprene residues. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data

M.Wt:
404.54
Formula:
C24H36O5
Solubility:
Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
75330-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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⚠ WARNING: This product can expose you to chemicals including Lovastatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Lovastatin

The citations listed below are publications that use Tocris products. Selected citations for Lovastatin include:

11 Citations: Showing 1 - 10

  1. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.
    Authors: Roche Et al.
    J Cell Biol  2018;217:3560
  2. Mapping the Genetic Landscape of Human Cells.
    Authors: Horlbeck Et al.
    Cell  2018;174:953
  3. Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.
    Authors: Leznicki Et al.
    J Cell Sci  2018;131
  4. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
    Authors: Park Et al.
    Nat Immunol  2016;17:914
  5. Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.
    Authors: Saqcena Et al.
    Oncotarget  2015;14:2285
  6. The Effects of Targeted Deliveries of lovas. and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model.
    Authors: Ibrahim Et al.
    Int J Environ Res Public Health  2015;12:12958
  7. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
    Authors: Rojo-Arreola Et al.
    PLoS One  2014;9:e87594
  8. Combination of 13-Cis retinoic acid and lovastatin: marked antitumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice.
    Authors: Nölting Et al.
    Endocrinology  2014;155:2377
  9. A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.
    Authors: Buchovecky Et al.
    Nat Genet  2013;45:1013
  10. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression.
    Authors: Kah Et al.
    Oncol Rep  2012;28:1077

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GTPase inhibitor
By Mengxi Lv on 03/26/2018
Application: Species: Other

used as Rho GTPase activity inhibitor


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