Chemical Name: (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate
Biological ActivityLovastatin is a potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Indirectly inhibits Rho-GTPase activity by depleting intracellular pool of isoprene residues. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alberts et al.
Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis.
Park et al.
Anticancer Res., 1999;19:3133
Rho inhibition by lovas. affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation.
Ziegler et al.
Cell Death Dis., 2017;8:e2978
Discovery, biochemistry and biology of lovas.
Citations for Lovastatin
The citations listed below are publications that use Tocris products. Selected citations for Lovastatin include:
11 Citations: Showing 1 - 10
Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.
Authors: Roche Et al.
J Cell Biol 2018;217:3560
Mapping the Genetic Landscape of Human Cells.
Authors: Horlbeck Et al.
Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.
Authors: Leznicki Et al.
J Cell Sci 2018;131
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Authors: Park Et al.
Nat Immunol 2016;17:914
Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.
Authors: Saqcena Et al.
The Effects of Targeted Deliveries of lovas. and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model.
Authors: Ibrahim Et al.
Int J Environ Res Public Health 2015;12:12958
Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
Authors: Rojo-Arreola Et al.
PLoS One 2014;9:e87594
Combination of 13-Cis retinoic acid and lovastatin: marked antitumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice.
Authors: Nölting Et al.
A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.
Authors: Buchovecky Et al.
Nat Genet 2013;45:1013
Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression.
Authors: Kah Et al.
Oncol Rep 2012;28:1077
Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT.
Authors: Vainio Et al.
J Neurosci 2011;2:1176
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used as Rho GTPase activity inhibitor