Lovastatin

Tocris Bioscience | Catalog # 1530

Potent HMG-CoA reductase inhibitor
Tocris Bioscience

Key Product Details

Description

Potent HMG-CoA reductase inhibitor

Alternative Names

Mevinolin
View all HMG-CoA Reductase Inhibitors »

Product Description

Lovastatin is a potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Indirectly inhibits Rho-GTPase activity by depleting intracellular pool of isoprene residues. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Product Specifications for Lovastatin

Molecular Weight

404.54

Formula

C24H36O5

Storage

Store at +4°C

Purity

≥97% (HPLC)

Chemical Name

(2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate

CAS Number

75330-75-5

PubChem ID

53232

InChI Key

PCZOHLXUXFIOCF-BXMDZJJMSA-N

SMILES

[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.45 100
Ethanol 20.23 50 with gentle warming

Preparing Stock Solutions for Lovastatin

The following data is based on the product molecular weight 404.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.72 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

Product Documents for Lovastatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Lovastatin

For research use only

⚠ WARNING: This product can expose you to chemicals including Lovastatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Customer Reviews for Lovastatin (1)

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  • GTPase inhibitor
    Name: Mengxi Lv
    Species: Bovine
    Assay Type: In Vitro
    Cell Line/Tissue: chondrocyte
    Verified Customer | Posted 03/26/2018
    used as Rho GTPase activity inhibitor
    Lovastatin 1530

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