Chemical Name: [8β(1S,2R)]-N-(2-Hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-ergoline-8-carboxamide
Biological ActivityLY 215840 is a 5-HT2/5-HT7 receptor antagonist. Reduces stimulatory effect of serotonin on aldosterone secretion; also reduces 5-HT-induced cAMP formation (pKB = 8.26).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery.
Cushing et al.
Activation of 5-HT7 receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels.
Lenglet et al.
Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome.
Louiset et al.
Citations for LY 215840
The citations listed below are publications that use Tocris products. Selected citations for LY 215840 include:
4 Citations: Showing 1 - 4
A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.
Authors: Chan Et al.
PLoS Pathog 2016;12:e1005651
Ergot Alkaloids (Re)generate New Leads as Antiparasitics.
Authors: Chan Et al.
BMC Neurosci 2015;9:e0004063
5-HT is a potent relaxant in rat superior mesenteric veins.
Authors: Watts Et al.
PLoS Negl Trop Dis 2015;3:e00103
Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.
Authors: Du Et al.
FASEB J 2015;29:2194
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for LY 215840
Average Rating: 3 (Based on 1 Review)
Have you used LY 215840?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
1nM 5-HT7 receptor antagonists LY215840