Chemical Name: [8β(1S,2R)]-N-(2-Hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-ergoline-8-carboxamide
Biological ActivityLY 215840 is a 5-HT2/5-HT7 receptor antagonist. Reduces stimulatory effect of serotonin on aldosterone secretion; also reduces 5-HT-induced cAMP formation (pKB = 8.26).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery.
Cushing et al.
Activation of 5-HT7 receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels.
Lenglet et al.
Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome.
Louiset et al.
Citations for LY 215840
The citations listed below are publications that use Tocris products. Selected citations for LY 215840 include:
4 Citations: Showing 1 - 4
A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.
Authors: Chan Et al.
PLoS Pathog 2016;12:e1005651
Ergot Alkaloids (Re)generate New Leads as Antiparasitics.
Authors: Chan Et al.
BMC Neurosci 2015;9:e0004063
5-HT is a potent relaxant in rat superior mesenteric veins.
Authors: Watts Et al.
PLoS Negl Trop Dis 2015;3:e00103
Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.
Authors: Du Et al.
FASEB J 2015;29:2194
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1nM 5-HT7 receptor antagonists LY215840