LY 341495

  ( 55 citations )    
Product Datasheet
Catalog Number:1209
Chemical Name:(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid
Product Details
Citations (55)
Supplemental Products
Reviews
Biological Activity
Highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8, mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo. Disodium salt (Cat. No. 4062) also available. Also available as part of the Group II mGlu Receptor Tocriset™, Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    353.37
  • Formula:
    C20H19NO5
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming and to 100 mM in 1.2eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    201943-63-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 341495 include:

55 Citations: Showing 1 - 10
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  1. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
    Authors: Lafourcade Et al.
    PLoS One  ;2:e709
  2. Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
    Authors: Dornier
    Nat Commun  2017;8(1):2255
  3. Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
    Authors: Scholler
    Nat Commun  2017;8(1):1967
  4. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  5. Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum
    Authors: Johnson
    Neuropharmacology  2017;117:114
  6. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Mol Pain  2015;63:383
  7. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    J Neurosci  2015;4
  8. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
    Authors: Choi Et al.
    Psychopharmacology (Berl)  2015;35:396
  9. Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.
    Authors: Dunn
    Elife  2015;35:2423
  10. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
    Authors: Carbonaro Et al.
    Front Neural Circuits  2015;232:275
  11. Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
    Authors: Johansson Et al.
    Cell Rep.  2015;13:1741
  12. N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans.
    Authors: Truini Et al.
    J Neurosci  2015;11:14
  13. Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism.
    Authors: Chen Et al.
    J Neurophysiol  2014;8:219
  14. VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit.
    Authors: Case Et al.
    J Neurosci  2014;8:140
  15. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
    Authors: Grimes Et al.
    Elife  2014;3:e03892
  16. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
    Authors: Gee Et al.
    J Biol Chem  2014;289:10975
  17. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
    Authors: Mahler Et al.
    J Neurosci  2014;19:49
  18. Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice.
    Authors: Miyamoto Et al.
    Int J Neuropsychopharmacol  2014;17:1283
  19. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    Neurosci Lett  2013;8:e61787
  20. Properties of the ON bistratified ganglion cell in the rabbit retina.
    Authors: Hoshi Et al.
    J Comp Neurol  2013;521:1497
  21. Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase.
    Authors: Trepanier Et al.
    Sci Rep  2013;3:926
  22. Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
    Authors: Hulme Et al.
    J Neurosci  2012;32:6785
  23. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
    Authors: Marrocco Et al.
    Acta Crystallogr Sect F Struct Biol Cryst Commun  2012;32:17143
  24. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res  2012;287:43
  25. A non-canonical pathway for mammalian blue-green color vision.
    Authors: Sher and DeVries
    Nat Neurosci  2012;15:952
  26. Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.
    Authors: Peachey Et al.
    Brain Res  2012;108:2442
  27. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
    Authors: Taman and Ribeiro
    PLoS One  2011;6:e27119
  28. Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
    Authors: Johnson Et al.
    Addict Biol  2011;504:102
  29. A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites.
    Authors: Pearring Et al.
    Proc Natl Acad Sci U S A  2011;31:10060
  30. Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis.
    Authors: Jin Et al.
    Learn Mem  2011;18:96
  31. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
    Authors: Ster Et al.
    J Endocrinol  2011;108:9993
  32. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron  2010;68:948
  33. Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
    Authors: Fuortes Et al.
    Epilepsia  2010;51:1633
  34. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A  2010;30:3870
  35. The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
    Authors: Chen Et al.
    Psychopharmacology (Berl)  2010;209:343
  36. Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain.
    Authors: Muto Et al.
    Proc Natl Acad Sci U S A  2009;65:236
  37. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    Neuropsychopharmacology  2009;30:1443
  38. A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.
    Authors: Sekizawa Et al.
    J Neurosci  2009;29:11807
  39. Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
    Authors: Carlton Et al.
    Eur J Neurosci  2009;1248:86
  40. Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.
    Authors: Olszewski Et al.
    Biol Psychiatry  2008;63:86
  41. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells.
    Authors: Sheffler and Conn
    Neuropharmacology  2008;55:419
  42. Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine.
    Authors: Baker Et al.
    J Neurosci  2008;33:1760
  43. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
    Authors: Kaushal and Schlichter
    Glia  2008;28:2221
  44. Endocytosis and recycling of AMPA receptors lacking GluR2/3.
    Authors: Biou Et al.
    PLoS One  2008;105:1038
  45. Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells.
    Authors: Russo Et al.
    J Neurophysiol  2008;100:3351
  46. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron  2007;54:599
  47. Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
    Authors: Brager and Johnston
    J Neurosci  2007;27:13926
  48. Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.
    Authors: Duguid Et al.
    J Neurosci  2007;27:12464
  49. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
    Authors: Galici Et al.
    J Pharmacol Exp Ther  2006;318:173
  50. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci  2006;26:4166
  51. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol  2006;16:1591
  52. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well a
    Authors: Wang Et al.
    J Neurosci  2004;24:3370
  53. Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.
    Authors: Fujino and Oertel
    Proc Natl Acad Sci U S A  2003;100:265
  54. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
    Authors: Moore Et al.
    Proc Natl Acad Sci U S A  2003;100:14397
  55. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
    Authors: Nishi Et al.
    Front Behav Neurosci  2003;100:1322
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