LY 341495

Tocris Bioscience | Catalog # 1209

Highly potent and selective group II mGlu antagonist
Tocris Bioscience

Key Product Details

Description

Highly potent and selective group II mGlu antagonist
View all Group II mGluR Antagonists »

Product Description

LY 341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8, mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo.

Disodium salt (Cat. No. 4062) also available.

Licensing Information

Sold with the permission of Eli Lilly and Company

Product Specifications for LY 341495

Molecular Weight

353.37

Formula

C20H19NO5

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid

CAS Number

201943-63-7

PubChem ID

9819927

InChI Key

VLZBRVJVCCNPRJ-KPHUOKFYSA-N

SMILES

[H][C@]4([C@@H]([C@](O)=O)C4)[C@](N)(C(O)=O)CC2C3=C(C=CC=C3)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.77 5 with gentle warming
1.2eq. NaOH 35.34 100

Preparing Stock Solutions for LY 341495

The following data is based on the product molecular weight 353.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.30 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Calculators

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Product Documents for LY 341495

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 341495

For research use only

Customer Reviews for LY 341495 (2)

4.5 out of 5
2 Customer Ratings
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  • Slice Electrophysiology
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 04/09/2019
    Used in slice electrophysiology experiments to inhibit mGluR3/4 at a concentration of 1uM
  • physiology assay
    Name: Anonymous
    Assay Type: In Vivo
    Verified Customer | Posted 10/11/2018
    physiology assay

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