Highly potent and selective group II metabotropic glutamate receptor antagonist (K
values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu
receptors respectively). Readily brain penetrant and active
(Cat. No. 4062) also available. Also available as part of the
Group II mGlu Receptor Tocriset™
Group III mGlu Receptor Tocriset™
Mixed mGlu Receptor Tocriset™
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of Eli Lilly and Company
The citations listed below are publications that use Tocris products.
Selected citations for LY 341495 include:
Citations: Showing 1 -
Filter your results:
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
Authors: Lafourcade Et al.
PLoS One ;2:e709
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
Nat Commun 2017;8(1):2255
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
Nat Commun 2017;8(1):1967
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol 2017;13(4):372
Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum
Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
Authors: Garthwaite Et al.
Mol Pain 2015;63:383
Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
Authors: Rosa Et al.
J Neurosci 2015;4
PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
Authors: Choi Et al.
Psychopharmacology (Berl) 2015;35:396
Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.
The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
Authors: Carbonaro Et al.
Front Neural Circuits 2015;232:275
Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
Authors: Johansson Et al.
Cell Rep. 2015;13:1741
N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans.
Authors: Truini Et al.
J Neurosci 2015;11:14
Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism.
Authors: Chen Et al.
J Neurophysiol 2014;8:219
VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit.
Authors: Case Et al.
J Neurosci 2014;8:140
Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
Authors: Grimes Et al.
Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
Authors: Gee Et al.
J Biol Chem 2014;289:10975
Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Authors: Mahler Et al.
J Neurosci 2014;19:49
Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice.
Authors: Miyamoto Et al.
Int J Neuropsychopharmacol 2014;17:1283
Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
Authors: Wang Et al.
Neurosci Lett 2013;8:e61787
Properties of the ON bistratified ganglion cell in the rabbit retina.
Authors: Hoshi Et al.
J Comp Neurol 2013;521:1497
Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase.
Authors: Trepanier Et al.
Sci Rep 2013;3:926
Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
Authors: Hulme Et al.
J Neurosci 2012;32:6785
Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
Authors: Marrocco Et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2012;32:17143
Intrinsic modulators of auditory thalamocortical transmission.
Authors: Lee and Sherman
Hear Res 2012;287:43
A non-canonical pathway for mammalian blue-green color vision.
Authors: Sher and DeVries
Nat Neurosci 2012;15:952
Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.
Authors: Peachey Et al.
Brain Res 2012;108:2442
Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
Authors: Taman and Ribeiro
PLoS One 2011;6:e27119
Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
Authors: Johnson Et al.
Addict Biol 2011;504:102
A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites.
Authors: Pearring Et al.
Proc Natl Acad Sci U S A 2011;31:10060
Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis.
Authors: Jin Et al.
Learn Mem 2011;18:96
Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
Authors: Ster Et al.
J Endocrinol 2011;108:9993
Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
Authors: Buchanan Et al.
Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
Authors: Fuortes Et al.
Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
Authors: Kim Et al.
Proc Natl Acad Sci U S A 2010;30:3870
The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
Authors: Chen Et al.
Psychopharmacology (Berl) 2010;209:343
Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain.
Authors: Muto Et al.
Proc Natl Acad Sci U S A 2009;65:236
N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
Authors: Citri Et al.
A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.
Authors: Sekizawa Et al.
J Neurosci 2009;29:11807
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
Authors: Carlton Et al.
Eur J Neurosci 2009;1248:86
Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.
Authors: Olszewski Et al.
Biol Psychiatry 2008;63:86
Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells.
Authors: Sheffler and Conn
Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine.
Authors: Baker Et al.
J Neurosci 2008;33:1760
Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
Authors: Kaushal and Schlichter
Endocytosis and recycling of AMPA receptors lacking GluR2/3.
Authors: Biou Et al.
PLoS One 2008;105:1038
Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells.
Authors: Russo Et al.
J Neurophysiol 2008;100:3351
Neuregulin-1 enhances depolarization-induced GABA release.
Authors: Woo Et al.
Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
Authors: Brager and Johnston
J Neurosci 2007;27:13926
Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.
Authors: Duguid Et al.
J Neurosci 2007;27:12464
Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
Authors: Galici Et al.
J Pharmacol Exp Ther 2006;318:173
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
Authors: Bender Et al.
J Neurosci 2006;26:4166
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
Authors: Proudfoot Et al.
Curr Biol 2006;16:1591
Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well a
Authors: Wang Et al.
J Neurosci 2004;24:3370
Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.
Authors: Fujino and Oertel
Proc Natl Acad Sci U S A 2003;100:265
Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
Authors: Moore Et al.
Proc Natl Acad Sci U S A 2003;100:14397
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
Authors: Nishi Et al.
Front Behav Neurosci 2003;100:1322
Expand to show all Citations
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQs
Have you used LY 341495?
Submit a Review
Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.