Highly potent and selective group II metabotropic glutamate receptor antagonist (K
values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu
receptors respectively). Readily brain penetrant and active
(Cat. No. 4062) also available. Also available as part of the
Group II mGlu Receptor Tocriset™
Group III mGlu Receptor Tocriset™
Mixed mGlu Receptor Tocriset™
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of Eli Lilly and Company
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
Fitzjohn et al.
[ 3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
Johnson et al.
LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.
Kingston et al.
2-Substituted (2SR)-2-amino-2-((1 SR,2 SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav
Ornstein et al.
The citations listed below are publications that use Tocris products. Selected citations for LY 341495 include:
44 Citations: Showing 1 - 10 Filter your results:
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. Authors: Lafourcade Et al. PLoS One ;2:e709 HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Authors: Scholler Nat Chem Biol 2017;13(4):372 Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. Authors: Garthwaite Et al. Mol Pain 2015;63:383 Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. Authors: Rosa Et al. J Neurosci 2015;4 PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome. Authors: Choi Et al. Psychopharmacology (Berl) 2015;35:396 Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina. Authors: Dunn Elife 2015;35:2423 The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice. Authors: Carbonaro Et al. Front Neural Circuits 2015;232:275 Activation of a temporal memory in purkinje cells by the mGluR7 receptor. Authors: Johansson Et al. Cell Rep. 2015;13:1741 N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. Authors: Truini Et al. J Neurosci 2015;11:14 Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism. Authors: Chen Et al. J Neurophysiol 2014;8:219 VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit. Authors: Case Et al. J Neurosci 2014;8:140 Cross-synaptic synchrony and transmission of signal and noise across the mouse retina. Authors: Grimes Et al. Elife 2014;3:e03892 Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Authors: Mahler Et al. J Neurosci 2014;19:49 Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice. Authors: Miyamoto Et al. Int J Neuropsychopharmacol 2014;17:1283 Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. Authors: Wang Et al. Neurosci Lett 2013;8:e61787 Properties of the ON bistratified ganglion cell in the rabbit retina. Authors: Hoshi Et al. J Comp Neurol 2013;521:1497 Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase. Authors: Trepanier Et al. Sci Rep 2013;3:926 Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. Authors: Marrocco Et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012;32:17143 Intrinsic modulators of auditory thalamocortical transmission. Authors: Lee and Sherman Hear Res 2012;287:43 A non-canonical pathway for mammalian blue-green color vision. Authors: Sher and DeVries Nat Neurosci 2012;15:952 Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation. Authors: Peachey Et al. Brain Res 2012;108:2442 Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni. Authors: Taman and Ribeiro PLoS One 2011;6:e27119 Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata. Authors: Johnson Et al. Addict Biol 2011;504:102 A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites. Authors: Pearring Et al. Proc Natl Acad Sci U S A 2011;31:10060 Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. Authors: Ster Et al. J Endocrinol 2011;108:9993 Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Authors: Buchanan Et al. Neuron 2010;68:948 Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation. Authors: Fuortes Et al. Epilepsia 2010;51:1633 Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals. Authors: Kim Et al. Proc Natl Acad Sci U S A 2010;30:3870 The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice. Authors: Chen Et al. Psychopharmacology (Berl) 2010;209:343 Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain. Authors: Muto Et al. Proc Natl Acad Sci U S A 2009;65:236 N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system. Authors: Citri Et al. Neuropsychopharmacology 2009;30:1443 A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission. Authors: Sekizawa Et al. J Neurosci 2009;29:11807 Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function. Authors: Carlton Et al. Eur J Neurosci 2009;1248:86 Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors. Authors: Olszewski Et al. Biol Psychiatry 2008;63:86 Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine. Authors: Baker Et al. J Neurosci 2008;33:1760 Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. Authors: Kaushal and Schlichter Glia 2008;28:2221 Endocytosis and recycling of AMPA receptors lacking GluR2/3. Authors: Biou Et al. PLoS One 2008;105:1038 Neuregulin-1 enhances depolarization-induced GABA release. Authors: Woo Et al. Neuron 2007;54:599 Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. Authors: Galici Et al. J Pharmacol Exp Ther 2006;318:173 Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. Authors: Bender Et al. J Neurosci 2006;26:4166 Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Authors: Proudfoot Et al. Curr Biol 2006;16:1591 Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus. Authors: Fujino and Oertel Proc Natl Acad Sci U S A 2003;100:265 Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses. Authors: Moore Et al. Proc Natl Acad Sci U S A 2003;100:14397 Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Authors: Nishi Et al. Front Behav Neurosci 2003;100:1322
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