Catalog Number: 1209
Chemical Name: (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid
Biological Activity
Highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8, mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo. Disodium salt (Cat. No. 4062) also available. Also available as part of the Group II mGlu Receptor Tocriset™, Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    353.37
  • Formula:
    C20H19NO5
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming and to 100 mM in 1.2eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    201943-63-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Background References
  1. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
    Fitzjohn et al.
    Neuropharmacology, 1998;37:1445
  2. [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
    Johnson et al.
    Neuropharmacology, 1999;38:1519
  3. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.
    Kingston et al.
    Neuropharmacology, 1998;37:1
  4. 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav
    Ornstein et al.
    J.Med.Chem., 1998;41:358
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 341495 include:

44 Citations: Showing 1 - 10
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  1. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
    Authors: Lafourcade Et al.
    PLoS One ;2:e709
  2. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  3. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Mol Pain 2015;63:383
  4. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    J Neurosci 2015;4
  5. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
    Authors: Choi Et al.
    Psychopharmacology (Berl) 2015;35:396
  6. Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.
    Authors: Dunn
    Elife 2015;35:2423
  7. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
    Authors: Carbonaro Et al.
    Front Neural Circuits 2015;232:275
  8. Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
    Authors: Johansson Et al.
    Cell Rep. 2015;13:1741
  9. N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans.
    Authors: Truini Et al.
    J Neurosci 2015;11:14
  10. Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism.
    Authors: Chen Et al.
    J Neurophysiol 2014;8:219
  11. VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit.
    Authors: Case Et al.
    J Neurosci 2014;8:140
  12. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
    Authors: Grimes Et al.
    Elife 2014;3:e03892
  13. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
    Authors: Mahler Et al.
    J Neurosci 2014;19:49
  14. Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice.
    Authors: Miyamoto Et al.
    Int J Neuropsychopharmacol 2014;17:1283
  15. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    Neurosci Lett 2013;8:e61787
  16. Properties of the ON bistratified ganglion cell in the rabbit retina.
    Authors: Hoshi Et al.
    J Comp Neurol 2013;521:1497
  17. Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase.
    Authors: Trepanier Et al.
    Sci Rep 2013;3:926
  18. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
    Authors: Marrocco Et al.
    Acta Crystallogr Sect F Struct Biol Cryst Commun 2012;32:17143
  19. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res 2012;287:43
  20. A non-canonical pathway for mammalian blue-green color vision.
    Authors: Sher and DeVries
    Nat Neurosci 2012;15:952
  21. Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.
    Authors: Peachey Et al.
    Brain Res 2012;108:2442
  22. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
    Authors: Taman and Ribeiro
    PLoS One 2011;6:e27119
  23. Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
    Authors: Johnson Et al.
    Addict Biol 2011;504:102
  24. A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites.
    Authors: Pearring Et al.
    Proc Natl Acad Sci U S A 2011;31:10060
  25. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
    Authors: Ster Et al.
    J Endocrinol 2011;108:9993
  26. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron 2010;68:948
  27. Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
    Authors: Fuortes Et al.
    Epilepsia 2010;51:1633
  28. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A 2010;30:3870
  29. The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
    Authors: Chen Et al.
    Psychopharmacology (Berl) 2010;209:343
  30. Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain.
    Authors: Muto Et al.
    Proc Natl Acad Sci U S A 2009;65:236
  31. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    Neuropsychopharmacology 2009;30:1443
  32. A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.
    Authors: Sekizawa Et al.
    J Neurosci 2009;29:11807
  33. Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
    Authors: Carlton Et al.
    Eur J Neurosci 2009;1248:86
  34. Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.
    Authors: Olszewski Et al.
    Biol Psychiatry 2008;63:86
  35. Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine.
    Authors: Baker Et al.
    J Neurosci 2008;33:1760
  36. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
    Authors: Kaushal and Schlichter
    Glia 2008;28:2221
  37. Endocytosis and recycling of AMPA receptors lacking GluR2/3.
    Authors: Biou Et al.
    PLoS One 2008;105:1038
  38. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron 2007;54:599
  39. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
    Authors: Galici Et al.
    J Pharmacol Exp Ther 2006;318:173
  40. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci 2006;26:4166
  41. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol 2006;16:1591
  42. Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.
    Authors: Fujino and Oertel
    Proc Natl Acad Sci U S A 2003;100:265
  43. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
    Authors: Moore Et al.
    Proc Natl Acad Sci U S A 2003;100:14397
  44. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
    Authors: Nishi Et al.
    Front Behav Neurosci 2003;100:1322
Expand to show all 44 Citations
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LY 341495 disodium salt

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