Catalog Number: 4062
Chemical Name: (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt
Biological Activity
Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 (Cat. No. 1209).
Technical Data
  • M.Wt:
    397.33
  • Formula:
    C20H17NNa2O5
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >97%
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
    Fitzjohn et al.
    Neuropharmacology, 1998;37:1445
  2. [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
    Johnson et al.
    Neuropharmacology, 1999;38:1519
  3. 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav
    Ornstein et al.
    J.Med.Chem., 1998;41:358
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 341495 disodium salt include:

1 Citations: Showing 1 - 1

  1. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol 2013;305:C1050
Tocris Small Molecules
Description Application Cat# Citations Images  

LY 341495

1209 44  
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