TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50
= 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.
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All Tocris products are intended for laboratory research use only.
Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice.
Nakamura M, Shimizu Y, Sato Y, Miyazaki Y, Satoh T, Mizuno M, Kato Y, Hosaka Y, Furusako S
Eur. J. Pharmacol., 2007;569(3):237-43.