M62812

Catalog # Availability Size / Price Qty
5705/10
5705/50
M62812 | CAS No. 613263-00-6 | Toll-like Receptor Inhibitors
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Description: TLR-4 inhibitor

Chemical Name: 6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride

Purity: ≥98%

Product Details
Supplemental Products
Reviews (1)

Biological Activity

TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

Technical Data

M.Wt:
330.23
Formula:
C13H11N3OS.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
613263-00-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice.
    Nakamura M, Shimizu Y, Sato Y, Miyazaki Y, Satoh T, Mizuno M, Kato Y, Hosaka Y, Furusako S
    Eur. J. Pharmacol., 2007;569(3):237-43.

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Ok, needs titrations
By Scott Scarneo on 02/06/2019
Application: Species: Mouse

We were interested in looking at LPS TLR4 mediated signaling and were hoping to use this to block this.


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