E-Cadherin/Cadherin-1 (ECAD) Is a transmembrane cell adhesion protein. It forms homophilic clusters between epithelial cells and is a critical component of adherens junctions. These junctions are critical for the maintenance of the epithelial barrier and epithelial tissue homeostasis. Decreased E-Cadherin is associated with physiological and pathological epithelial-to-mesenchymal transition (EMT) and cell migration, and E-Cadherin loss contributes to cancer metastasis. The shed ECD is released as a soluble factor that enhances cancer cell motility and EGFR-dependent survival and proliferation.
MagCellect Plus Human E-Cadherin+ Cell Isolation Kit
R&D Systems | Catalog # MAGH123
Discontinued Product
MAGH123 has been discontinued.
View all E-Cadherin products.
Key Product Details
Species
Human
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Background: E-Cadherin
Alternate Names
Arc-1, CAD1, Cadherin-1, CD324, CDH1, Cell-CAM120/80, ECAD, ECadherin, L-CAM, Uvomorulin
Gene Symbol
CDH1
Additional E-Cadherin Products
Product Documents for MagCellect Plus Human E-Cadherin+ Cell Isolation Kit
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for MagCellect Plus Human E-Cadherin+ Cell Isolation Kit
For research use only
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FAQs for MagCellect Plus Human E-Cadherin+ Cell Isolation Kit
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Q: When using MacCellect Cell Isolation kits (MAGM*** or MAGH***), why is it important to lyse red blood cells before starting the cell isolation protocol?
A: It is important to remove red blood cells before the isolation protocol using MagCellect isolation kits because not doing so can cause a poorer yield of selected cells. Red blood cells become sticky during the incubation protocols and may interfere with the interactions needed for removal of unwanted populations.
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Associated Pathways
