Control analog of 6-bromoindirubin-3'-oxime (BIO
, Cat. No. 3194). Displays minimal activity against CDK1/Cyclin B, GSK-3 α
, and CDK5/p25 (IC50
values are 92.0, 44-100 and >100 μ
M respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
Soluble to 10 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Polychronopoulos et al.
GSK-3-selective inhibitors derived from tyrian purple indirubins.
Meijer et al.
Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins.
Knockaert et al.