MeBIO

Key Product Details

Product Description

MeBIO is a control analog of 6-bromoindirubin-3'-oxime (BIO). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC₅₀ values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Active Analog also available.

Product Specifications for MeBIO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MeBIO

The following data is based on the product molecular weight 370.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.01 mL	135.06 mL	270.12 mL
0.5 mM	5.40 mL	27.01 mL	54.02 mL
1 mM	2.70 mL	13.51 mL	27.01 mL
5 mM	0.54 mL	2.70 mL	5.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Meijer GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 2003 PMID: 14700633
• Polychronopoulos Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 2004 PMID: 14761195
• Knockaert Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 2004 PMID: 15077192

Product Documents for MeBIO