Catalog Number: 3873
Chemical Name: (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime
Biological Activity
Control analog of 6-bromoindirubin-3'-oxime (BIO). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Active Analog also available.

Technical Data
  • M.Wt:
    370.2
  • Formula:
    C17H12BrN3O2
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    667463-95-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
    Polychronopoulos et al.
    J.Med.Chem., 2004;47:935
  2. GSK-3-selective inhibitors derived from tyrian purple indirubins.
    Meijer et al.
    Chem.Biol., 2003;10:1255
  3. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins.
    Knockaert et al.
    Oncogene, 2004;23:4400
Tocris Small Molecules
Description Application Cat# Citations Images  

BIO

3194 10  
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