BIO

Catalog # Availability Size / Price Qty
3194/10
3194/50
Cat.No. 3194 - BIO | C16H10BrN3O2 | CAS No. 667463-62-9
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Description: Potent GSK-3 inhibitor; also inhibits cdks
Alternative Names: 6BIO

Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-oxime

Purity: ≥98%

Product Details
Citations (14)
Supplemental Products
Reviews

Biological Activity

Potent ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 5 nM). Also inhibits cyclin-dependent kinases (cdks; IC50 values are <100 nM for cdk2 and 5 and sub micromolar for cdk1, cdk4 and cdk9). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro; also promotes proliferation and dedifferentiation in cardiomyocytes.

Negative Control also available.

Technical Data

M.Wt:
356.17
Formula:
C16H10BrN3O2
Solubility:
Soluble to 10 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
667463-62-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for BIO

The citations listed below are publications that use Tocris products. Selected citations for BIO include:

14 Citations: Showing 1 - 10

  1. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
    Authors: Diamantopoulou Et al.
    Cancer Cell  2017;31:621
  2. Wnt signalling is a bi-directional vulnerability of cancer cells.
    Authors: Duffy Et al.
    Oncotarget  2016;7:60310
  3. A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells.
    Authors: Rhim Et al.
    Elife  2015;5:16237
  4. A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction.
    Authors: Pronobis Et al.
    Cell  2015;4:e08022
  5. Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
    Authors: Efthymiou Et al.
    Elife  2015;4:230
  6. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
    Authors: Lindstr&#246;m Et al.
    Nat Chem Biol  2015;3:e04000
  7. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.
    Authors: Penas Et al.
    Nat Commun  2015;14:417
  8. GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
    Authors: Zhang Et al.
    PLoS Biol  2015;13:e1002129
  9. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
    Authors: Thorne Et al.
    Stem Cells Transl Med  2015;11:58
  10. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.
    Authors: Naujok Et al.
    BMC Res Notes  2014;7:273

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