Memantine hydrochloride

Catalog # Availability Size / Price Qty
Memantine hydrochloride | CAS No. 41100-52-1 | NMDA Receptor Antagonists
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Description: NMDA antagonist; acts at ion channel site

Chemical Name: 3,5-Dimethyl-tricyclo[,7]decan-1-amine hydrochloride

Product Details
Citations (17)
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Biological Activity

Memantine hydrochloride is an antagonist at the NMDA receptor (IC50 = 0.5 -1.5 μM in vitro), binding to the ion channel site. Memantine increases BDNF protein and mRNA levels in the brain in vivo. In an animal model of Alzheimer's disease, memantine improves spatial learning and decreases deposition of Aβ plaques. Memantine has neuroprotective effects in dopaminergic neurons; stimulates release of neurotrophic factor from astroglia and reduces microglia inflammation in vitro.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Memantine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Memantine hydrochloride include:

17 Citations: Showing 1 - 10

  1. Cognitive enhancer effects of low Mem. doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in rats.
    Authors: Bali Et al.
    Front Pharmacol  2019;10:73
  2. Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche.
    Authors: Bouchard-Cannon Et al.
    Sci Rep  2018;8:5294
  3. Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca(2+) channels, and calcineurin.
    Authors: Sachser Et al.
    Sci Rep  2016;6:22771
  4. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Invest Ophthalmol Vis Sci  2015;8:425
  5. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
    Authors: Birnbaum Et al.
    J Neurosci  2015;6:e1791
  6. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    J Neurosci  2014;77:379
  7. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
    Authors: Simma Et al.
    Front Cell Neurosci  2014;12:75
  8. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int  2012;61:601
  9. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    Cell Death Dis  2012;32:3992
  10. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
    Authors: Carlson Et al.
    Brain Behav  2012;2:391


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