Catalog Number: 0773
Chemical Name: 3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
Biological Activity
An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.
Technical Data
  • M.Wt:
    215.77
  • Formula:
    C12H21N.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    41100-52-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.
    Zajaczkowski et al.
    Neuropharmacology, 1997;36:961
  2. Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.
    Chen et al.
    Neuroscience, 1998;86:1121
  3. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - a review of preclinical data.
    Parsons et al.
    Neuropharmacology, 1999;38:735
  4. Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse.
    Parsons et al.
    Neuropharmacology, 2007;53:699
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Memantine hydrochloride include:

13 Citations: Showing 1 - 10
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  1. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Invest Ophthalmol Vis Sci 2015;8:425
  2. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
    Authors: Birnbaum Et al.
    J Neurosci 2015;6:e1791
  3. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    J Neurosci 2014;77:379
  4. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
    Authors: Simma Et al.
    Front Cell Neurosci 2014;12:75
  5. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int 2012;61:601
  6. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    Cell Death Dis 2012;32:3992
  7. Glutamate-induced NFκB activation in the retina.
    Authors: Fan and Cooper
    Proc Natl Acad Sci U S A 2009;50:917
  8. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes.
    Authors: Puddifoot Et al.
    Br J Pharmacol 2009;156:509
  9. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci 2008;28:8040
  10. NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia.
    Authors: Manning Et al.
    Cell Commun Signal 2008;28:6670
  11. Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
    Authors: Léveillé Et al.
    FASEB J 2008;22:4258
  12. Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons.
    Authors: Jaekel Et al.
    Neuropharmacology 2006;147:622
  13. Glutamate antagonists limit tumor growth.
    Authors: Rzeski Et al.
    FASEB J 2001;98:6372
Expand to show all 13 Citations
Tocris Small Molecules
Description Application Cat# Citations Images  

Memantine - d6 hydrochloride

5531  
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