Chemical Name: 3,5-Dimethyl-tricyclo[22.214.171.124,7]decan-1-amine hydrochloride
Biological ActivityMemantine hydrochloride is an antagonist at the NMDA receptor (IC50 = 0.5 -1.5 μM in vitro), binding to the ion channel site. Memantine increases BDNF protein and mRNA levels in the brain in vivo. In an animal model of Alzheimer's disease, memantine improves spatial learning and decreases deposition of Aβ plaques. Memantine has neuroprotective effects in dopaminergic neurons; stimulates release of neurotrophic factor from astroglia and reduces microglia inflammation in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Neuroprotective concentrations of the N-MthD.-aspartate open-channel blocker Mem. are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.
Chen et al.
Mem.: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse.
Parsons et al.
Mem. is a clinically well tolerated N-MthD.-aspartate (NMDA) receptor antagonist - a review of preclinical data.
Parsons et al.
Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.
Zajaczkowski et al.
Citations for Memantine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Memantine hydrochloride include:
17 Citations: Showing 1 - 10
Cognitive enhancer effects of low Mem. doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in rats.
Authors: Bali Et al.
Front Pharmacol 2019;10:73
Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche.
Authors: Bouchard-Cannon Et al.
Sci Rep 2018;8:5294
Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca(2+) channels, and calcineurin.
Authors: Sachser Et al.
Sci Rep 2016;6:22771
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
Authors: Campbell Et al.
Invest Ophthalmol Vis Sci 2015;8:425
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
Authors: Birnbaum Et al.
J Neurosci 2015;6:e1791
Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
Authors: He and Bausch
J Neurosci 2014;77:379
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Authors: Simma Et al.
Front Cell Neurosci 2014;12:75
Molecular pharmacology of human NMDA receptors.
Authors: Hedegaard Et al.
Neurochem Int 2012;61:601
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
Authors: Kaufman Et al.
Cell Death Dis 2012;32:3992
Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
Authors: Carlson Et al.
Brain Behav 2012;2:391
Glutamate-induced NFκB activation in the retina.
Authors: Fan and Cooper
Proc Natl Acad Sci U S A 2009;50:917
Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes.
Authors: Puddifoot Et al.
Br J Pharmacol 2009;156:509
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
Authors: Costa Et al.
J Neurosci 2008;28:8040
NMDA receptor blockade with Mem. attenuates white matter injury in a rat model of periventricular leukomalacia.
Authors: Manning Et al.
Cell Commun Signal 2008;28:6670
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
Authors: Léveillé Et al.
FASEB J 2008;22:4258
Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons.
Authors: Jaekel Et al.
Glutamate antagonists limit tumor growth.
Authors: Rzeski Et al.
FASEB J 2001;98:6372
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