Memantine hydrochloride

  ( 15 citations )    
Product Datasheet
Catalog Number:0773
Chemical Name:3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
Product Details
Citations (15)
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Reviews
Biological Activity
An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.

Deuterated analog also available.

Technical Data
  • M.Wt:
    215.77
  • Formula:
    C12H21N.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    41100-52-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Memantine hydrochloride include:

15 Citations: Showing 1 - 10
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  1. Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca(2+) channels, and calcineurin.
    Authors: Sachser Et al.
    Sci Rep  2016;6:22771
  2. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Invest Ophthalmol Vis Sci  2015;8:425
  3. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
    Authors: Birnbaum Et al.
    J Neurosci  2015;6:e1791
  4. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    J Neurosci  2014;77:379
  5. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
    Authors: Simma Et al.
    Front Cell Neurosci  2014;12:75
  6. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int  2012;61:601
  7. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    Cell Death Dis  2012;32:3992
  8. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
    Authors: Carlson Et al.
    Brain Behav  2012;2:391
  9. Glutamate-induced NFκB activation in the retina.
    Authors: Fan and Cooper
    Proc Natl Acad Sci U S A  2009;50:917
  10. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes.
    Authors: Puddifoot Et al.
    Br J Pharmacol  2009;156:509
  11. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci  2008;28:8040
  12. NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia.
    Authors: Manning Et al.
    Cell Commun Signal  2008;28:6670
  13. Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
    Authors: Léveillé Et al.
    FASEB J  2008;22:4258
  14. Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons.
    Authors: Jaekel Et al.
    Neuropharmacology  2006;147:622
  15. Glutamate antagonists limit tumor growth.
    Authors: Rzeski Et al.
    FASEB J  2001;98:6372
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Tocris Small Molecules
Description Application Cat# Citations Images  

Memantine - d6 hydrochloride

5531  
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VersaClone cDNA Plasmids
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Human GRIN2B/NMDAR2B (NP_000825) VersaClone cDNA

RDC1221
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Human GRIN2A/NMDAR2A (NP_000824) VersaClone cDNA

RDC1220
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Human GRIN1/NMDAR1 (NP_015566) VersaClone cDNA

RDC1219
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