BDNF (human)

Catalog # Availability Size / Price Qty
2837/10U
BDNF (human)
1 Image
Description: Activates TrkB and p75 receptors

Purity: ≥95%

Product Details
Citations (6)
Reviews (1)

Biological Activity

BDNF (human) is a member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. BDNF enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. In an animal model of Huntington's disease, BDNF administration or overexpression rescues the disease phenotype.

Technical Data

M.Wt:
26984
Solubility:
Soluble in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
218441-99-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity.
    Lipsky and Marini
    Ann.N.Y.Acad.Sci., 2007;1122:130
  2. Neurotrophic factors as a therapeutic target for Parkinson's disease.
    Evans and Barker
    Expert Opin.Ther.Targets, 2008;12:437

Product Datasheets

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Increases neurite outgrowth in human neurons
By Karthik Krishnamurthy on 11/15/2021
Application: Species: Human

Used at a concentration of 10 ng/ml. Increases neurite growth in human iPS neurons. The image shows the labeling of MAP-2 in human iPS neurons treated with BDNF for a week.


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