MK 886

Catalog # Availability Size / Price Qty
MK 886 | CAS No. 118414-82-7 | Lipoxygenase Inhibitors
1 Image
Description: Inhibitor of 5-lipoxygenase-activating protein (FLAP)
Alternative Names: L-663,536

Chemical Name: 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid

Purity: ≥98%

Product Details
Citations (11)
Supplemental Products

Biological Activity

MK 886 is a potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Also moderately potent PPARα antagonist (IC50 = 0.5-1 μM). Orally active in vivo.

Technical Data

Soluble to 5 mM in ethanol and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for MK 886

The citations listed below are publications that use Tocris products. Selected citations for MK 886 include:

11 Citations: Showing 1 - 10

  1. The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
    Authors: Oguh-Olayinka Et al.
    Pathol Oncol Res  2019;
  2. Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice.
    Authors: Shahid Et al.
    J Neuroinflammation  2015;1:75
  3. PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.
    Authors: Puligheddu Et al.
    PLoS One  2013;8:e64541
  4. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis.
    Authors: Rizvi Et al.
    Vascul Pharmacol  2013;59:144
  5. The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.
    Authors: Eisele Et al.
    J Biol Chem  2013;288:2246
  6. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury.
    Authors: Roversi Et al.
    J Biol Chem  2013;288:18789
  7. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
    Authors: Scuderi Et al.
    J Pharmacol Exp Ther  2012;9:49
  8. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
    Authors: Esposito Et al.
    Cell Mol Gastroenterol Hepatol  2011;6:e28668
  9. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
    Authors: Mascia Et al.
    Biol Psychiatry  2011;69:633
  10. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.
    Authors: Vigna Et al.
    Pancreas  2011;40:708


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