MK 886

Key Product Details

Product Description

MK 886 is a potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC₅₀ = 30 nM for inhibition of [¹²⁵I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC₅₀ = 3 nM in human polymorphonuclear leukocytes). Also moderately potent PPARα antagonist (IC₅₀ = 0.5-1 μM). Orally active in vivo.

Product Specifications for MK 886

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MK 886

The following data is based on the product molecular weight 472.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.59 mL	21.18 mL
5 mM	0.42 mL	2.12 mL	4.24 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

• Mancini 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol.Pharmacol. 1992 PMID: 1538707
• Gillard L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can.J.Physiol.Pharmacol. 1989 PMID: 2548691
• Kehrer Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886. Biochem.J. 2001 PMID: 11389700
• Dixon Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 1990 PMID: 2300173

Product Documents for MK 886