MK 886

Catalog # Availability Size / Price Qty
1311/10
1311/50
Cat.No. 1311 - MK 886 | C27H34ClNO2S | CAS No. 118414-82-7
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Description: Inhibitor of 5-lipoxygenase-activating protein (FLAP)
Alternative Names: L-663,536

Chemical Name: 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid

Purity: ≥98%

Product Details
Citations (10)
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Reviews

Biological Activity

An inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Also moderately potent PPARα antagonist (IC50 = 0.5-1 μM). Orally active in vivo.

Technical Data

M.Wt:
472.08
Formula:
C27H34ClNO2S
Solubility:
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
118414-82-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for MK 886

The citations listed below are publications that use Tocris products. Selected citations for MK 886 include:

10 Citations: Showing 1 - 10

  1. Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice.
    Authors: Shahid Et al.
    J Neuroinflammation  2015;1:75
  2. PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.
    Authors: Puligheddu Et al.
    PLoS One  2013;8:e64541
  3. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis.
    Authors: Rizvi Et al.
    Vascul Pharmacol  2013;59:144
  4. The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.
    Authors: Eisele Et al.
    J Biol Chem  2013;288:2246
  5. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury.
    Authors: Roversi Et al.
    J Biol Chem  2013;288:18789
  6. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
    Authors: Scuderi Et al.
    J Pharmacol Exp Ther  2012;9:49
  7. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
    Authors: Esposito Et al.
    Cell Mol Gastroenterol Hepatol  2011;6:e28668
  8. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
    Authors: Mascia Et al.
    Biol Psychiatry  2011;69:633
  9. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.
    Authors: Vigna Et al.
    Pancreas  2011;40:708
  10. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
    Authors: Melis Et al.
    J Neurosci  2008;28:13985

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