ML 337

Key Product Details

Product Description

ML 337 is a selective negative allosteric modulator of mGlu₃ (IC₅₀ = 593 nM). Displays no activity at mGlu₁, mGlu₂ or mGlu_4-8 at concentrations up to 30 μM. Brain penetrant.

Product Specifications for ML 337

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 337

The following data is based on the product molecular weight 353.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.30 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.41 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wenthur Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu₃ selective and CNS penetrant negative allosteric modulator (NAM). J.Med.Chem. 2013 PMID: 23718281

Product Documents for ML 337