MNI caged kainic acid

Tocris Bioscience | Catalog # 2225

Caged kainic acid
Tocris Bioscience
Discontinued Product
2225 has been discontinued. View all Caged Compounds products.

Key Product Details

Description

Caged kainic acid
View all Caged Compounds »

Product Description

Kainic acid

(Cat.No. 0222) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Generates large inward currents at resting membrane potential upon wide field photolysis in Purkinje neurons. Selectively photoactivates kainate receptors when used in conjunction with an AMPA antagonist, such as GYKI 53655 (Cat.No. 2555). Suitable for uncaging with 300-380 nm excitation. Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation. Also suitable for two-photon uncaging experiments at 720 nm.

Licensing Information

Sold under licence from the Medical Research Council

Product Specifications for MNI caged kainic acid

Molecular Weight

389.40

Formula

C19H23N3O6

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid 4-methoxy-7-nitro-1H-indolinyl amide

CAS Number

1315378-75-6

PubChem ID

57414719

InChI Key

IQGCUMUIYXHZOT-AHIWAGSCSA-N

SMILES

C=[C@@](C)[C@@H]1[C@H](CC(N2C(C([N+]([O-])=O)=CC=C3OC)=C3CC2)=O)[C@@H]([C@](O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.95 5 with gentle warming
DMSO 38.94 100

Preparing Stock Solutions for MNI caged kainic acid

The following data is based on the product molecular weight 389.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Product Documents for MNI caged kainic acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MNI caged kainic acid

For research use only

Citations for MNI caged kainic acid

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