MNI caged kainic acid

Discontinued Product

2225 has been discontinued.
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MNI caged kainic acid | CAS No. 1315378-75-6 | Caged Compounds
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Description: Caged kainic acid

Chemical Name: (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid 4-methoxy-7-nitro-1H-indolinyl amide

Purity: ≥99%

Product Details
Citations (1)

Biological Activity

Kainic acid (Cat.No. 0222) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Generates large inward currents at resting membrane potential upon wide field photolysis in Purkinje neurons. Selectively photoactivates kainate receptors when used in conjunction with an AMPA antagonist, such as GYKI 53655 (Cat.No. 2555). Suitable for uncaging with 300-380 nm excitation. Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation. Also suitable for two-photon uncaging experiments at 720 nm.

Technical Data

Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under licence from the Medical Research Council

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Citation for MNI caged kainic acid

The citations listed below are publications that use Tocris products. Selected citations for MNI caged kainic acid include:

1 Citation: Showing 1 - 1

  1. Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons.
    Authors: Passlick and Ellis-Davies
    J.Neurosci.Methods.  2017;293:321


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