GYKI 53655 hydrochloride

Key Product Details

Product Description

GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl₂- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC₅₀ = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC₅₀ = 32 μM) at high concentrations.

Product Specifications for GYKI 53655 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GYKI 53655 hydrochloride

The following data is based on the product molecular weight 388.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.86 mL	25.72 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

• Szabados Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res.Bull. 2001 PMID: 11489346
• Perrais Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology 2009 PMID: 18761361
• Paternain Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 1995 PMID: 7826635

Product Documents for GYKI 53655 hydrochloride