Catalog Number: 2555
Chemical Name: 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
Biological Activity
Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.
Technical Data
  • M.Wt:
    388.85
  • Formula:
    C19H20N4O3.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    143692-48-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons.
    Paternain et al.
    Neuron, 1995;14:185
  2. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.
    Szabados et al.
    Brain Res.Bull., 2001;55:387
  3. Antagonism of recombinant and native GluK3-containing kainate receptors.
    Perrais et al.
    Neuropharmacology, 2009;56:131
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GYKI 53655 hydrochloride include:

9 Citations: Showing 1 - 9
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  1. An excitatory GABA loop operating in vivo.
    Authors: Astorga Et al.
    Front Cell Neurosci 2015;9:275
  2. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
    Authors: Murphy-Baum and Taylor
    J Neurosci 2015;35:13336
  3. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    PLoS One 2015;12:396
  4. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Pharmacol Res Perspect 2015;10:e0131430
  5. Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.
    Authors: Höft Et al.
    Philos Trans R Soc Lond B Biol Sci 2014;369:20130602
  6. Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell.
    Authors: Buldyrev Et al.
    J Neurophysiol 2012;107:1795
  7. Neto1 is an auxiliary subunit of native synaptic kainate receptors.
    Authors: Tang Et al.
    Cell Rep 2011;31:10009
  8. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci 2011;14:866
  9. Excitability and synaptic communication within the oligodendrocyte lineage.
    Authors: Biase Et al.
    J Neurosci 2010;30:3600

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