GYKI 53655 hydrochloride

  ( 9 citations )    
Product Datasheet
Catalog Number:2555
Chemical Name:1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
Product Details
Citations (9)
Reviews
Biological Activity
Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.
Technical Data
  • M.Wt:
    388.85
  • Formula:
    C19H20N4O3.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    143692-48-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GYKI 53655 hydrochloride include:

9 Citations: Showing 1 - 9
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  1. An excitatory GABA loop operating in vivo.
    Authors: Astorga Et al.
    Front Cell Neurosci  2015;9:275
  2. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
    Authors: Murphy-Baum and Taylor
    J Neurosci  2015;35:13336
  3. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    PLoS One  2015;12:396
  4. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Pharmacol Res Perspect  2015;10:e0131430
  5. Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.
    Authors: Höft Et al.
    Philos Trans R Soc Lond B Biol Sci  2014;369:20130602
  6. Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell.
    Authors: Buldyrev Et al.
    J Neurophysiol  2012;107:1795
  7. Neto1 is an auxiliary subunit of native synaptic kainate receptors.
    Authors: Tang Et al.
    Cell Rep  2011;31:10009
  8. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci  2011;14:866
  9. Excitability and synaptic communication within the oligodendrocyte lineage.
    Authors: Biase Et al.
    J Neurosci  2010;30:3600

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