GYKI 53655 hydrochloride
Chemical Name: 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
Biological ActivityGYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Antagonism of recombinant and native GluK3-containing kainate receptors.
Perrais et al.
Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons.
Paternain et al.
Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.
Szabados et al.
Brain Res.Bull., 2001;55:387
Citations for GYKI 53655 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for GYKI 53655 hydrochloride include:
11 Citations: Showing 1 - 10
Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters.
Authors: Lu Et al.
Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes.
Authors: Droste Et al.
Sci Rep 2017;7:44817
An excitatory GABA loop operating in vivo.
Authors: Astorga Et al.
Front Cell Neurosci 2015;9:275
The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
Authors: Murphy-Baum and Taylor
J Neurosci 2015;35:13336
A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
Authors: Ben-Simon Et al.
PLoS One 2015;12:396
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
Pharmacol Res Perspect 2015;10:e0131430
Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.
Authors: Höft Et al.
Philos Trans R Soc Lond B Biol Sci 2014;369:20130602
Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell.
Authors: Buldyrev Et al.
J Neurophysiol 2012;107:1795
Neto1 is an auxiliary subunit of native synaptic kainate receptors.
Authors: Tang Et al.
Cell Rep 2011;31:10009
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
Authors: Straub Et al.
Nat Neurosci 2011;14:866
Excitability and synaptic communication within the oligodendrocyte lineage.
Authors: Biase Et al.
J Neurosci 2010;30:3600
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