Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466
(Cat. No. 1454). Prolongs the survival time after MgCl2
- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50
= 63 μ
M) and GluK2b(R)/GluK3 heteroreceptors (IC50
= 32 μ
M) at high concentrations.
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All Tocris products are intended for laboratory research use only.
Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons.
Paternain et al.
Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.
Szabados et al.
Brain Res.Bull., 2001;55:387
Antagonism of recombinant and native GluK3-containing kainate receptors.
Perrais et al.
The citations listed below are publications that use Tocris products. Selected citations for GYKI 53655 hydrochloride include:
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