GYKI 53655 hydrochloride
Chemical Name: 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
Biological ActivityNon-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonism of recombinant and native GluK3-containing kainate receptors.
Perrais et al.
Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons.
Paternain et al.
Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.
Szabados et al.
Brain Res.Bull., 2001;55:387
Citations for GYKI 53655 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for GYKI 53655 hydrochloride include:
11 Citations: Showing 1 - 10
Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters.
Authors: Lu Et al.
Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes.
Authors: Droste Et al.
Sci Rep 2017;7:44817
An excitatory GABA loop operating in vivo.
Authors: Astorga Et al.
Front Cell Neurosci 2015;9:275
The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
Authors: Murphy-Baum and Taylor
J Neurosci 2015;35:13336
A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
Authors: Ben-Simon Et al.
PLoS One 2015;12:396
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
Pharmacol Res Perspect 2015;10:e0131430
Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.
Authors: Höft Et al.
Philos Trans R Soc Lond B Biol Sci 2014;369:20130602
Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell.
Authors: Buldyrev Et al.
J Neurophysiol 2012;107:1795
Neto1 is an auxiliary subunit of native synaptic kainate receptors.
Authors: Tang Et al.
Cell Rep 2011;31:10009
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
Authors: Straub Et al.
Nat Neurosci 2011;14:866
Excitability and synaptic communication within the oligodendrocyte lineage.
Authors: Biase Et al.
J Neurosci 2010;30:3600
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