Kainic acid

  ( 30 citations )    
Product Datasheet
Catalog Number:0222
Chemical Name:(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
Product Details
Citations (30)
Supplemental Products
Reviews
Biological Activity
Selective agonist at kainate receptors. Potent excitant and neurotoxin. Also available as part of the Kainate Receptor Tocriset™.
Technical Data
  • M.Wt:
    213.23
  • Formula:
    C10H15NO4
  • Solubility:
    Soluble to 25 mM in water with gentle warming
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    487-79-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Kainic acid include:

30 Citations: Showing 1 - 10
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  1. Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptortype IB protects neurons against kainic acid-induced neurodegeneration.
    Authors: Zhao
    Neurosci Lett  2017;651:36
  2. Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.
    Authors: Fletcher
    Nat Neurosci  2017;20(7):905
  3. Assembly, secretory pathway trafficking, and surface delivery of kainate receptors is regulated by neuronal activity.
    Authors: Evans
    Cell Rep  2017;19(12):2613
  4. Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation.
    Authors: Park Et al.
    Invest Ophthalmol Vis Sci  2016;57:508
  5. Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
    Authors: Szokol Et al.
    J Biol Chem  2015;9:49
  6. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.
    Authors: Spampinato Et al.
    Neurotox Res  2015;8:462
  7. In vitro gamma oscillations following partial and complete ablation of δ subunit-containing GABAA receptors from parvalbumin interneurons.
    Authors: Ferando and Mody
    Neuropharmacology  2015;88:91
  8. Methionine increases BDNF DNA methylation and improves memory in epilepsy.
    Authors: Parrish Et al.
    Neurobiol Dis  2015;2:401
  9. CX3 chemokine receptor 1 deficiency leads to reduced dendritic complexity and delayed maturation of newborn neurons in the adult mouse hippocampus.
    Authors: Xiao Et al.
    Front Cell Neurosci  2015;10:772
  10. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
    Authors: Chang Et al.
    Neurobiol Dis  2014;62:296
  11. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo.
    Authors: Domin Et al.
    Ann Clin Transl Neurol  2014;26:99
  12. Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish.
    Authors: deCarvalho Et al.
    Front Neural Circuits  2013;7:98
  13. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits  2013;7:144
  14. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    Nat Commun  2013;59:42736
  15. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy.
    Authors: Krook-Magnuson Et al.
    J Neurosci  2013;4:1376
  16. Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
    Authors: Hou and Yu
    Neural Regen Res  2013;288:2501
  17. The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex.
    Authors: Neves Et al.
    Cereb Cortex  2013;23:1811
  18. Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus.
    Authors: Chuang Et al.
    J Neuroinflammation  2012;9:184
  19. Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds.
    Authors: Horita Et al.
    PLoS One  2012;7:e42173
  20. Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds.
    Authors: Huang Et al.
    PLoS One  2012;7:e30662
  21. Real-time detection of acetylcholine release from the human endocrine pancreas.
    Authors: Rodriguez-Diaz Et al.
    Nat Protoc  2012;7:1015
  22. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
    Authors: Marrocco Et al.
    Proc Natl Acad Sci U S A  2012;32:17143
  23. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
    Authors: Doyon Et al.
    J Neurosci  2011;7:e1002149
  24. Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
    Authors: Wang and Green
    J Neurosci  2011;31:7938
  25. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.
    Authors: Hitt Et al.
    Mol Neurodegener  2010;5:31
  26. Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
    Authors: Peng Et al.
    J Neurosci  2010;30:16220
  27. Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.
    Authors: Fritsch Et al.
    Neuroscience  2009;163:415
  28. Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy.
    Authors: Shin Et al.
    Neurobiol Dis  2008;32:26
  29. TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.
    Authors: Milstein Et al.
    Neuron  2007;55:905
  30. Galanin acts as a neuroprotective factor to the hippocampus.
    Authors: Elliott-Hunt Et al.
    PLoS Comput Biol  2004;101:5105
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