Kainic acid

Tocris Bioscience | Catalog # 0222

Kainate agonist; excitant and neurotoxin
Tocris Bioscience
Discontinued Product
0222 has been discontinued. An alternative/replacement product is available: 7065. View all Kainate Receptor Agonists products.

Key Product Details

Description

Kainate agonist; excitant and neurotoxin
View all Kainate Receptor Agonists »

Product Description

Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 - 7.4 μM) and a partial agonist at AMPA receptors (EC50 = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's disease.

Related compounds include synthetic Kainic acid (Cat. No. 7065), the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).

Product Specifications for Kainic acid

Molecular Weight

213.23

Formula

C10H15NO4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid

CAS Number

487-79-6

PubChem ID

10255

InChI Key

VLSMHEGGTFMBBZ-OOZYFLPDSA-N

SMILES

C=[C@@](C)[C@@H]1[C@H](CC(O)=O)[C@@H]([C@](O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.33 25 with gentle warming

Preparing Stock Solutions for Kainic acid

The following data is based on the product molecular weight 213.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 18.76 mL 93.80 mL 187.59 mL
1.25 mM 3.75 mL 18.76 mL 37.52 mL
2.5 mM 1.88 mL 9.38 mL 18.76 mL
12.5 mM 0.38 mL 1.88 mL 3.75 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 77 publications citing the usage of this product.

Product Documents for Kainic acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Kainic acid

For research use only

Customer Reviews for Kainic acid (1)

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  • Each animal receives 7.5 m/k of KA. Dosing every 1/2 after the first initial hour. Until 2 stage 4-5 seizures has been seen.
    Name: Jenny Huff
    Species: Rat
    Verified Customer | Posted 05/17/2019
    Rats were given KA to produce a spontaneous seizing animal to experiment with epileptic compounds.

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