Kainic acid

  ( 30 citations )    
Product Datasheet
Catalog Number:0222
Chemical Name:(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
Product Details
Citations (30)
Supplemental Products
Biological Activity
Selective agonist at kainate receptors. Potent excitant and neurotoxin. Also available as part of the Kainate Receptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:

The citations listed below are publications that use Tocris products. Selected citations for Kainic acid include:

30 Citations: Showing 1 - 10
Filter your results:

  1. Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptortype IB protects neurons against kainic acid-induced neurodegeneration.
    Authors: Zhao
    Neurosci Lett  2017;651:36
  2. Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.
    Authors: Fletcher
    Nat Neurosci  2017;20(7):905
  3. Assembly, secretory pathway trafficking, and surface delivery of kainate receptors is regulated by neuronal activity.
    Authors: Evans
    Cell Rep  2017;19(12):2613
  4. Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation.
    Authors: Park Et al.
    Invest Ophthalmol Vis Sci  2016;57:508
  5. Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
    Authors: Szokol Et al.
    J Biol Chem  2015;9:49
  6. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.
    Authors: Spampinato Et al.
    Neurotox Res  2015;8:462
  7. In vitro gamma oscillations following partial and complete ablation of δ subunit-containing GABAA receptors from parvalbumin interneurons.
    Authors: Ferando and Mody
    Neuropharmacology  2015;88:91
  8. Methionine increases BDNF DNA methylation and improves memory in epilepsy.
    Authors: Parrish Et al.
    Neurobiol Dis  2015;2:401
  9. CX3 chemokine receptor 1 deficiency leads to reduced dendritic complexity and delayed maturation of newborn neurons in the adult mouse hippocampus.
    Authors: Xiao Et al.
    Front Cell Neurosci  2015;10:772
  10. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
    Authors: Chang Et al.
    Neurobiol Dis  2014;62:296
  11. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo.
    Authors: Domin Et al.
    Ann Clin Transl Neurol  2014;26:99
  12. Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish.
    Authors: deCarvalho Et al.
    Front Neural Circuits  2013;7:98
  13. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits  2013;7:144
  14. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    Nat Commun  2013;59:42736
  15. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy.
    Authors: Krook-Magnuson Et al.
    J Neurosci  2013;4:1376
  16. Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
    Authors: Hou and Yu
    Neural Regen Res  2013;288:2501
  17. The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex.
    Authors: Neves Et al.
    Cereb Cortex  2013;23:1811
  18. Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus.
    Authors: Chuang Et al.
    J Neuroinflammation  2012;9:184
  19. Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds.
    Authors: Horita Et al.
    PLoS One  2012;7:e42173
  20. Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds.
    Authors: Huang Et al.
    PLoS One  2012;7:e30662
  21. Real-time detection of acetylcholine release from the human endocrine pancreas.
    Authors: Rodriguez-Diaz Et al.
    Nat Protoc  2012;7:1015
  22. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
    Authors: Marrocco Et al.
    Proc Natl Acad Sci U S A  2012;32:17143
  23. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
    Authors: Doyon Et al.
    J Neurosci  2011;7:e1002149
  24. Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
    Authors: Wang and Green
    J Neurosci  2011;31:7938
  25. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.
    Authors: Hitt Et al.
    Mol Neurodegener  2010;5:31
  26. Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
    Authors: Peng Et al.
    J Neurosci  2010;30:16220
  27. Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.
    Authors: Fritsch Et al.
    Neuroscience  2009;163:415
  28. Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy.
    Authors: Shin Et al.
    Neurobiol Dis  2008;32:26
  29. TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.
    Authors: Milstein Et al.
    Neuron  2007;55:905
  30. Galanin acts as a neuroprotective factor to the hippocampus.
    Authors: Elliott-Hunt Et al.
    PLoS Comput Biol  2004;101:5105
Expand to show all Citations


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Kainic acid?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order


Customer Information

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee