Plexin B2 is a 240 kDa member of the B subfamily, Plexin family of semaphorin receptors. It is expressed by cerebellar granule cells, neuroepithelium and chondrocytes and serves as a receptor for Sema4C. Mature human Plexin B2 is 1819 amino acid (aa) in length. It is a type I transmembrane (TM) glycoprotein that contains an 1178 aa extracellular domain (ECD) plus a 620 aa cytoplasmic region. The ECD contains one semaphorin domain (aa 20 - 466) and three IPT repeats (aa 803 - 1092). The ECD may be cleaved into two subunits, a 170 kDa alpha-chain (aa 20 - 1164) and an 80 kDa TM beta-chain that remain noncovalently-linked. Multiple splice variants may exist. One shows an alternate start site at Met1369, while a second shows a deletion of aa 67 - 638. Over aa 20 - 1160, human Plexin B2 is 82% aa identical to mouse Plexin B2.
Mouse Plexin B2 (NP_620088.2) VersaClone cDNA
R&D Systems | Catalog # RDC3316
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Plexin B2
Alternate Names
MM1, PLEXB2, PLXNB2
Gene Symbol
PLXNB2
UniProt
Additional Plexin B2 Products
Product Documents for Mouse Plexin B2 (NP_620088.2) VersaClone cDNA
Product Specific Notices for Mouse Plexin B2 (NP_620088.2) VersaClone cDNA
For research use only
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