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The SLITRK family of integral membrane proteins consists of at least 6 members (SLITRK1-6). They are named for the presence of two leucine-rich repeats (LRR) in the extracellular domain similar to those found in the Slit family, and a C-terminal domain with homology to Trk tyrosine kinase receptors. SLITRKs are expressed mainly in the brain, but may also show differential expression in other normal tissues and nervous system-derived tumors. Functionally, SLITRKs may modulate neurite outgrowth, and sequence variants of SLITRK1 have been linked to Tourette's syndrome.
SLIT and NTRK-like Family, Member 5
Entrez Gene IDs:
26050 (Human); 75409 (Mouse); 306152 (Rat)
bA364G4.2; FLJ58374; KIAA0918; leucine-rich repeat-containing protein 11; LRRC11; SLIT and NTRK-like family, member 5; SLIT and NTRK-like protein 5; SLITRK5
Have you used Mouse SLITRK5 (NP_942565) VersaClone cDNA?
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