MPEP hydrochloride

Tocris Bioscience | Catalog # 1212

Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
Tocris Bioscience

Key Product Details

Description

Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
View all Group I mGluR Antagonists »

Product Description

MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Product Specifications for MPEP hydrochloride

Molecular Weight

229.71

Formula

C14H11N.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Methyl-6-(phenylethynyl)pyridine hydrochloride

CAS Number

219911-35-0

PubChem ID

9794588

InChI Key

PKDHDJBNEKXCBI-UHFFFAOYSA-N

SMILES

Cl.CC1=CC=CC(=N1)C#CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.15 5 with gentle warming
DMSO 22.97 100

Preparing Stock Solutions for MPEP hydrochloride

The following data is based on the product molecular weight 229.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.35 mL 21.77 mL 43.53 mL
5 mM 0.87 mL 4.35 mL 8.71 mL
10 mM 0.44 mL 2.18 mL 4.35 mL
50 mM 0.09 mL 0.44 mL 0.87 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 103 publications citing the usage of this product.

Product Documents for MPEP hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MPEP hydrochloride

For research use only

Citations for MPEP hydrochloride

Customer Reviews for MPEP hydrochloride (4)

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Showing  1 - 4 of 4 reviews Showing All
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  • Used in inhibitor cocktail
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Retinal rod bipolar cells
    Verified Customer | Posted 12/03/2019
    Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail with 50 umol/L MPEP
    MPEP hydrochloride 1212
  • mGluR5 antagonist （10 µM)
    Name: Kang Peng
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: auditory brainstem（MNTB）
    Verified Customer | Posted 09/18/2018
    mGluR5 antagonist (10 µM)
  • mGluR5 antagonist
    Name: Kang Peng
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 06/05/2018
    We use MPEP Hydrochloride as the mGluR5 antagonist in 10 uM.
  • Succesfull block of mGluRs
    Name: Anonymous
    Assay Type: In Vitro
    Verified Customer | Posted 11/02/2017
    We use bath application of CPCCOEt and MPEP to block mGluRs.

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