Chemical Name: N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea
Biological ActivityMRE 3008F20 is a potent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation.
Gessi et al.
Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes.
Varani et al.
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
Baraldi et al.
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