Catalog Number: 4041
Chemical Name: N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea
Biological Activity
Potent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).
Technical Data
  • M.Wt:
    432.44
  • Formula:
    C21H20N8O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    252979-43-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation.
    Gessi et al.
    Mol.Pharmacol., 2004;65:711
  2. Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes.
    Varani et al.
    Br.J.Pharmacol., 2010;160:101
  3. Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
    Baraldi et al.
    J.Med.Chem., 1999;42:4473

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