Potent adenosine A3
receptor competitive antagonist. Selective for human A3
receptors over human A1
values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50
= 5 nM).
Soluble to 50 mM in DMSO
Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation.
Gessi et al.
Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes.
Varani et al.
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
Baraldi et al.