MRE 3008F20

Key Product Details

Product Description

MRE 3008F20 is a potent adenosine A₃ receptor competitive antagonist. Selective for human A₃ receptors over human A₁ and A_2A receptors (K_i values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC₅₀ = 5 nM).

Product Specifications for MRE 3008F20

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MRE 3008F20

The following data is based on the product molecular weight 432.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.62 mL	23.12 mL	46.25 mL
2.5 mM	0.92 mL	4.62 mL	9.25 mL
5 mM	0.46 mL	2.31 mL	4.62 mL
25 mM	0.09 mL	0.46 mL	0.92 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Varani Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br.J.Pharmacol. 2010 PMID: 20331607
• Baraldi Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. J.Med.Chem. 1999 PMID: 10579811
• Gessi Expression of A₃ adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol.Pharmacol. 2004 PMID: 14978250

Product Documents for MRE 3008F20