MSC 1186

Catalog # Availability Size / Price Qty
MSC 1186 | CAS No. 2871698-23-4 | SRPK3
1 Image
Description: Potent and selective SRPK family inhibitor

Chemical Name: N-[3-[[[2-(6-Chloro-7-fluoro-1H-benzimidazol-2-yl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide

Purity: ≥98%

Product Details

Biological Activity

MSC1186 is a potent and selective inhibitor of serine arginine protein kinases (SRPK) 3, 1 and 2 (IC50 values are 0.6 nM, 3 nM and 81 nM respectively in biochemical assay; EC50 values in NanoBRETassay are 40 nM, 98 nM and 149 nM, respectively). Shows no activity at CLK and DYRK families (IC50 >10 μM).

External Portal Information is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MSC 1186 is reviewed on the chemical probes website.

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 1186 probe summary on the SGC website.

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).


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