N-Nonyldeoxynojirimycin

Key Product Details

Product Description

N-Nonyldeoxynojirimycin is a glucosidase inhibitor (IC₅₀ values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.

Product Specifications for N-Nonyldeoxynojirimycin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for N-Nonyldeoxynojirimycin

The following data is based on the product molecular weight 289.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.46 mL	17.28 mL	34.55 mL
5 mM	0.69 mL	3.46 mL	6.91 mL
10 mM	0.35 mL	1.73 mL	3.46 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mellor Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 2004 PMID: 15128289
• Sawkar Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA
• Andersson Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 2004 PMID: 14757169

Product Documents for N-Nonyldeoxynojirimycin