Catalog Number: 3648
Biological Activity
Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide.
Technical Data
  • M.Wt:
    4241.97
  • Formula:
    C193H307N57O49S
  • Sequence:
    LPRLLHTDSRMATIDFPKKDPTTSLGRPFFLFRPRN

    (Modifications: Asn-36 = C-terminal amide)

  • Solubility:
    Soluble to 0.50 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
    843782-19-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.
    Mori et al.
    EMBO J., 2005;24:325
  2. Neuromedin S is a novel anorexigenic hormone.
    Ida et al.
    Endocrinology, 2005;146:4217
  3. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.
    Mitchell et al.
    Br.J.Pharmacol., 2009;158:87

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