Neuromedin S (rat)
Biological Activity
Neuromedin S (rat) is a potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide.Technical Data
(Modifications: Asn-36 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.
Mori et al.
EMBO J., 2005;24:325 -
Neuromedin S is a novel anorexigenic hormone.
Ida et al.
Endocrinology, 2005;146:4217 -
Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.
Mitchell et al.
Br.J.Pharmacol., 2009;158:87
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Citation for Neuromedin S (rat)
The citations listed below are publications that use Tocris products. Selected citations for Neuromedin S (rat) include:
1 Citation: Showing 1 - 1
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Small-Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models.
Authors: Sampson Et al.
Pharmacol Res Perspect 2018;6:e00425
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