NF 110

Catalog # Availability Size / Price Qty
2548/10
2548/50
P2X Receptor Antagonists Small Molecule
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Description: Potent P2X3 antagonist

Chemical Name: 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt

Product Details
Citations (3)
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Biological Activity

High affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types.

Technical Data

M.Wt:
1096.9
Formula:
C41H28N6Na4O17S4
Solubility:
Soluble to 40 mM in water
Storage:
Desiccate at RT
CAS No:
111150-22-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NF 110

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3 Citations: Showing 1 - 3

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