Nicorandil

Catalog # Availability Size / Price Qty
2147/50
Nicorandil | CAS No. 65141-46-0 | Inward Rectifier Potassium Channel Activators
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Description: Kir6 (KATP) channel opener and NO donor

Chemical Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide

Product Details
Citations (1)
Reviews (1)

Biological Activity

Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Technical Data

M.Wt:
211.18
Formula:
C8H9N3O4
Solubility:
Soluble to 20 mM in water
Storage:
Desiccate at +4°C
CAS No:
65141-46-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Nicorandil

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Nicorandil was used to study Kca1.1 channels
By Sadequl Islam on 11/27/2018
Application: Species: Human

Nicorandil was used to study Kca1.1 channels which are are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. To understand neuronal excitability modulated by BK channel opening, Nicorandil was introduced into the cell line.


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