Biological Activity Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.
Soluble to 20 mM in water
Desiccate at +4°C
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