Chemical Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
Biological ActivityKir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.
Shindo et al.
Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat.
Horinaka et al.
Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil.
Gomma et al.
Citation for Nicorandil
The citations listed below are publications that use Tocris products. Selected citations for Nicorandil include:
1 Citation: Showing 1 - 1
Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart.
Authors: Killeen Et al.
Acta Physiol (Oxf) 2008;193:25
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Nicorandil was used to study Kca1.1 channels which are are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. To understand neuronal excitability modulated by BK channel opening, Nicorandil was introduced into the cell line.