Catalog Number: 2147
Chemical Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
Biological Activity
Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in water
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.
    Shindo et al.
    Br.J.Pharmacol., 1998;124:985
  2. Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat.
    Horinaka et al.
    J.Cardiovasc.Pharmacol., 2001;38:200
  3. Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil.
    Gomma et al.
    Drugs, 2001;61:1705
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