Nicorandil

Biological Activity

K_ir6 (K_ATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K_ir6 channels (EC₅₀ values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K⁺ channels by pinacidil and nicorandil.
   Shindo et al.
   Br.J.Pharmacol., 1998;124:985
2. Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat.
   Horinaka et al.
   J.Cardiovasc.Pharmacol., 2001;38:200
3. Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil.
   Gomma et al.
   Drugs, 2001;61:1705

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