Nicorandil
Chemical Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
Biological Activity
Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.
Shindo et al.
Br.J.Pharmacol., 1998;124:985 -
Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat.
Horinaka et al.
J.Cardiovasc.Pharmacol., 2001;38:200 -
Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil.
Gomma et al.
Drugs, 2001;61:1705
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Citation for Nicorandil
The citations listed below are publications that use Tocris products. Selected citations for Nicorandil include:
1 Citation: Showing 1 - 1
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Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart.
Authors: Killeen Et al.
Acta Physiol (Oxf) 2008;193:25
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Nicorandil was used to study Kca1.1 channels which are are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. To understand neuronal excitability modulated by BK channel opening, Nicorandil was introduced into the cell line.
