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2147 has been discontinued.
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Nicorandil | CAS No. 65141-46-0 | Inward Rectifier Potassium Channel Activators
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Description: Kir6 (KATP) channel opener and NO donor

Chemical Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide

Product Details
Citations (1)
Reviews (1)

Biological Activity

Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Technical Data

Soluble to 20 mM in water
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Nicorandil was used to study Kca1.1 channels
By Sadequl Islam on 11/27/2018
Application: Species: Human

Nicorandil was used to study Kca1.1 channels which are are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. To understand neuronal excitability modulated by BK channel opening, Nicorandil was introduced into the cell line.

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