NKH 477

  ( 7 citations )    
Product Datasheet
Catalog Number:1603
Alternate Names:Colforsin dapropate hydrochloride, 6-(3-dimethylaminopropionyl)forskolin hydrochloride
Chemical Name:N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride
Product Details
Citations (7)
Reviews
Biological Activity
Water-soluble analog of forskolin (Cat. No. 1099) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo. Also available as part of the PKA Tocriset™.
Technical Data
  • M.Wt:
    546.1
  • Formula:
    C27H43NO8.HCl
  • Solubility:
    Soluble to 40 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    138605-00-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NKH 477 include:

7 Citations: Showing 1 - 7
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  1. Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP1-17.
    Authors: Frieling
    Oncogene  2017;36(31):4498
  2. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
    Authors: Park Et al.
    Nat Immunol  2016;17:914
  3. Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis.
    Authors: Muschter Et al.
    PLoS One  2015;10:e0139726
  4. Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells.
    Authors: Brosnahan Et al.
    Cell Mol Neurobiol  2013;259:42583
  5. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  6. Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference.
    Authors: Zhong Et al.
    Neuropsychopharmacology  2012;37:2377
  7. Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format.
    Authors: Xia Et al.
    PLoS One  2011;31:901

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