Catalog Number: 3677
Chemical Name: N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide
Biological Activity
Potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.
Technical Data
  • M.Wt:
    351.44
  • Formula:
    C21H25N3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    439861-56-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.
    Block et al.
    J.Med.Chem., 2002;45:3509
  2. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats.
    Turnbull et al.
    Diabetes, 2002;51:2441
  3. Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors.
    Morris et al.
    Eur.J.Neurosci., 2007;25:1136
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NPY 5RA972 include:

1 Citations: Showing 1 - 1

  1. Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors.
    Authors: Zhang Et al.
    PLoS One 2015;10:e0131124

Have you used NPY 5RA972?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information