NPY 5RA972

Key Product Details

Product Description

Potent and selective neuropeptide Y Y₅ receptor antagonist (IC₅₀ values are 3.1, >10000, >10000 and >10000 nM for Y₅, Y₁, Y₂ and Y₄ receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.

Product Specifications for NPY 5RA972

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NPY 5RA972

The following data is based on the product molecular weight 351.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.45 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Turnbull Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 2002 PMID: 12145156
• Morris Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 2007 PMID: 17331209
• Block Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 2002 PMID: 12139462

Product Documents for NPY 5RA972