Chemical Name: N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide
Biological ActivityPotent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.
Block et al.
Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats.
Turnbull et al.
Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors.
Morris et al.
Citation for NPY 5RA972
The citations listed below are publications that use Tocris products. Selected citations for NPY 5RA972 include:
1 Citation: Showing 1 - 1
Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors.
Authors: Zhang Et al.
PLoS One 2015;10:e0131124
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