NS 6740
Discontinued Product
Chemical Name: 1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride
Purity: ≥98%
Biological Activity
NS 6740 is a high affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors.
Briggs et al.
Br.J.Pharmacol., 2009;158:1486 -
The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia.
Thomsen et al.
J.Neuroimmunol., 2012;251:65 -
The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.
Papke et al.
Neuropharmacology, 2015;91:34
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