NS 6740

Catalog # Availability Size / Price Qty
6139/10
6139/50
Cat.No. 6139 - NS 6740 | C19H19F3N2O2.HCl | CAS No. 753499-14-8
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Description: High affinity α7 nAChR partial agonist; anti-inflammatory

Chemical Name: 1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

High affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.

Technical Data

M.Wt:
400.82
Formula:
C19H19F3N2O2.HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
753499-14-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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