NS 6740

Catalog #: 6139 Datasheet / COA / SDS

Discontinued Product

6139 has been discontinued.
View all Nicotinic (a7) Receptor Agonists products.
NS 6740 | CAS No. 753499-14-8 | Nicotinic (a7) Receptor Agonists
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Description: High affinity α7 nAChR partial agonist; anti-inflammatory

Chemical Name: 1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride

Purity: ≥98%

Product Details

Biological Activity

NS 6740 is a high affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.

Technical Data

Soluble to 100 mM in water and to 50 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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