NS 8593 hydrochloride

Catalog # Availability Size / Price Qty
4597/10
4597/50
Cat.No. 4597 - NS 8593 hydrochloride | CAS No. 875755-24-1
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Description: Selective KCa2 (SK) channel negative modulator; inhibits SK currents

Chemical Name: N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.

Technical Data

M.Wt:
299.8
Formula:
C17H17N3.HCl
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
875755-24-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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