NS 8593 hydrochloride

Tocris Bioscience | Catalog # 4597

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents
Tocris Bioscience

Key Product Details

Description

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents
View all Ca2+-Activated Potassium Channel Blockers »

Product Description

NS 8593 hydrochloride is a selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.

Product Specifications for NS 8593 hydrochloride

Molecular Weight

299.80

Formula

C17H17N3.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride

CAS Number

875755-24-1

PubChem ID

71311765

InChI Key

VWEKCDTXUUPBNA-PFEQFJNWSA-N

SMILES

C12=CC=CC=C1N=C(N[C@H]3C(C=CC=C4)=C4CCC3)N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.98 100
Ethanol 6 20

Preparing Stock Solutions for NS 8593 hydrochloride

The following data is based on the product molecular weight 299.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.36 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Documents for NS 8593 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 8593 hydrochloride

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for NS 8593 hydrochloride

Customer Reviews for NS 8593 hydrochloride (1)

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  • NS 8593 worked great on experimental conditions
    Name: Sadequl Islam
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 10/13/2018
    The product was dissolved in DMSO. Sterile DMSO must be used for sterile cell culture studies.
    Product was used to study SK channel activity. Shows channel blocking activity and reduced Calcium activated opening. Great product, performs well and stable.
    NS 8593 hydrochloride 4597

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