NS 8593 hydrochloride

Catalog # Availability Size / Price Qty
4597/10
4597/50
NS 8593 hydrochloride | CAS No. 875755-24-1 | Ca2+-Activated Potassium Channel Blockers
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Description: Selective KCa2 (SK) channel negative modulator; inhibits SK currents

Chemical Name: N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.

Technical Data

M.Wt:
299.8
Formula:
C17H17N3.HCl
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
875755-24-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for NS 8593 hydrochloride

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Reviews for NS 8593 hydrochloride

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NS 8593 worked great on experimental conditions
By Sadequl Islam on 10/13/2018
Species: Mouse

Product was used to study SK channel activity. Shows channel blocking activity and reduced Calcium activated opening. Great product, performs well and stable.


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