A potent and selective inhibitor of NO-sensitive guanylyl cyclase.
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Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
Sci Rep 2017;7(1):10578
Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP-PKG-KATP Channel Signaling Pathway.
Authors: Manchope Et al.
PLoS One 2016;11:e0153015
Protein kinase G-regulated production of H2S governs oxygen sensing.
Authors: Yuan Et al.
Sci Signal 2015;8:ra37
Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
Authors: Garthwaite Et al.
Braz J Med Biol Res 2015;63:383
Central release of nitric oxide mediates antinociception induced by aerobic exercise.
Authors: Galdino Et al.
Proc Natl Acad Sci U S A 2015;48:790
Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
Authors: Padovan-Neto Et al.
Mol Cell Neurosci 2015;35:5781
Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.
Authors: Wallace Et al.
Proc Natl Acad Sci U S A 2015;3
NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
Authors: Bice Et al.
Cardiovasc Res 2014;101:220
Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats.
Authors: Ho Et al.
Cardiovasc Diabetol 2013;12:99
Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
Authors: Fakira Et al.
Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism.
Authors: Tseng Et al.
PLoS One 2011;6:e27187
Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
Authors: Chester Et al.
J Neurosci 2011;301:L755
Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks.
Authors: Moonen and Villamor
J Comp Physiol B 2011;181:1063
Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
Authors: Harnek Et al.
Exp Mol Med 2011;11:30
Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide.
Authors: Yoo Et al.
J Korean Med Sci 2010;25:1411
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Authors: Huang and Hsu
Cereb Cortex 2010;20:982
Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
Authors: Suri Et al.
Br J Pharmacol 2010;159:566
Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.
Authors: Chester Et al.
Am J Physiol Lung Cell Mol Physiol 2009;297:L318
Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
Authors: Hoffmann Et al.
Br J Pharmacol 2009;157:781
Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS.
Authors: Anselm Et al.
Cardiovasc Res 2007;73:404
Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities.
Authors: Dalsgaard Et al.
Am J Physiol Heart Circ Physiol 2007;292:H3072
Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors.
Authors: Makara Et al.
J Neurosci 2007;27:10211
Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction.
Authors: Newman Et al.
Eur J Neurosci 2007;25:1619
Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery.
Authors: McNeish Et al.
BMC Cardiovasc Disord 2006;37:1277
Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells.
Authors: Namkoong Et al.
J Pharmacol Exp Ther 2005;37:588
Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
Authors: Sachs Et al.
Proc Natl Acad Sci U S A 2004;101:3680
Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
Authors: Cirino Et al.
Am J Physiol Lung Cell Mol Physiol 2003;100:5531
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
Authors: Bellamy and Garthwaite
Br J Pharmacol 2002;136:95
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Authors: Stanford Et al.
Br J Pharmacol 2001;133:825
Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.
Authors: Hedlund Et al.
Physiol Rep 2000;97:2349
Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
Authors: Casado Et al.
A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle.
Br J Pharmacol 2000;130:685
Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter.
Authors: Mundey Et al.
Br J Pharmacol 2000;130:489
Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus.
Authors: Dick Et al.
Br J Pharmacol 2000;129:751
The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.
Authors: Aszódi Et al.
EMBO J 1999;18:37
Deficiency in myocardial NO biosignalling after cardioplegic arrest: mechanisms and contribution to post-storage mechanical dysfunction.
Authors: Rach Et al.
Br J Pharmacol 1999;128:891
PF9404C, a new slow NO donor with beta receptor blocking properties.
Authors: Villarroya Et al.
Br J Pharmacol 1999;128:1713
Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta.
Authors: Pérez-Vizcaíno Et al.
Br J Pharmacol 1999;128:1419
Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta.
Authors: Cogolludo Et al.
Br J Pharmacol 1999;126:1025
Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
Authors: Ruiz and Tejerina
Br J Pharmacol 1998;125:186
No evidence for a significant non-nitrergic, hyperpolarising factor contribution to field stimulation-induced relaxation of the mouse anococcygeus.
Authors: Fonseca Et al.
Br J Pharmacol 1998;124:524
Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries.
Authors: Prieto Et al.
Br J Pharmacol 1998;123:1609
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Authors: Fedele Et al.
Br J Pharmacol 1996;119:590
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