( 43 citations )    
Product Datasheet
Catalog Number:0880
Chemical Name:1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Product Details
Citations (43)
Biological Activity
A potent and selective inhibitor of NO-sensitive guanylyl cyclase.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for ODQ include:

43 Citations: Showing 1 - 10
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  1. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
    Authors: Cameron
    Sci Rep  2017;7(1):10578
  2. Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP-PKG-KATP Channel Signaling Pathway.
    Authors: Manchope Et al.
    PLoS One  2016;11:e0153015
  3. Protein kinase G-regulated production of H2S governs oxygen sensing.
    Authors: Yuan Et al.
    Sci Signal  2015;8:ra37
  4. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Braz J Med Biol Res  2015;63:383
  5. Central release of nitric oxide mediates antinociception induced by aerobic exercise.
    Authors: Galdino Et al.
    Proc Natl Acad Sci U S A  2015;48:790
  6. Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
    Authors: Padovan-Neto Et al.
    Mol Cell Neurosci  2015;35:5781
  7. Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.
    Authors: Wallace Et al.
    Proc Natl Acad Sci U S A  2015;3
  8. NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
    Authors: Bice Et al.
    Cardiovasc Res  2014;101:220
  9. Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats.
    Authors: Ho Et al.
    Cardiovasc Diabetol  2013;12:99
  10. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
    Authors: Fakira Et al.
    Glia  2012;51:22
  11. Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism.
    Authors: Tseng Et al.
    PLoS One  2011;6:e27187
  12. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
    Authors: Chester Et al.
    J Neurosci  2011;301:L755
  13. Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks.
    Authors: Moonen and Villamor
    J Comp Physiol B  2011;181:1063
  14. Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
    Authors: Harnek Et al.
    Exp Mol Med  2011;11:30
  15. Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide.
    Authors: Yoo Et al.
    J Korean Med Sci  2010;25:1411
  16. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  17. Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
    Authors: Suri Et al.
    Br J Pharmacol  2010;159:566
  18. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.
    Authors: Chester Et al.
    Am J Physiol Lung Cell Mol Physiol  2009;297:L318
  19. Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
    Authors: Hoffmann Et al.
    Br J Pharmacol  2009;157:781
  20. Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS.
    Authors: Anselm Et al.
    Cardiovasc Res  2007;73:404
  21. Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities.
    Authors: Dalsgaard Et al.
    Am J Physiol Heart Circ Physiol  2007;292:H3072
  22. Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors.
    Authors: Makara Et al.
    J Neurosci  2007;27:10211
  23. Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction.
    Authors: Newman Et al.
    Eur J Neurosci  2007;25:1619
  24. Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery.
    Authors: McNeish Et al.
    BMC Cardiovasc Disord  2006;37:1277
  25. Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells.
    Authors: Namkoong Et al.
    J Pharmacol Exp Ther  2005;37:588
  26. Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
    Authors: Sachs Et al.
    Proc Natl Acad Sci U S A  2004;101:3680
  27. Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
    Authors: Cirino Et al.
    Am J Physiol Lung Cell Mol Physiol  2003;100:5531
  28. Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
    Authors: Bellamy and Garthwaite
    Br J Pharmacol  2002;136:95
  29. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
    Authors: Stanford Et al.
    Br J Pharmacol  2001;133:825
  30. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.
    Authors: Hedlund Et al.
    Physiol Rep  2000;97:2349
  31. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Stroke  2000;97:11593
  32. A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle.
    Authors: Haynes
    Br J Pharmacol  2000;130:685
  33. Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter.
    Authors: Mundey Et al.
    Br J Pharmacol  2000;130:489
  34. Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus.
    Authors: Dick Et al.
    Br J Pharmacol  2000;129:751
  35. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.
    Authors: Aszódi Et al.
    EMBO J  1999;18:37
  36. Deficiency in myocardial NO biosignalling after cardioplegic arrest: mechanisms and contribution to post-storage mechanical dysfunction.
    Authors: Rach Et al.
    Br J Pharmacol  1999;128:891
  37. PF9404C, a new slow NO donor with beta receptor blocking properties.
    Authors: Villarroya Et al.
    Br J Pharmacol  1999;128:1713
  38. Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta.
    Authors: Pérez-Vizcaíno Et al.
    Br J Pharmacol  1999;128:1419
  39. Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta.
    Authors: Cogolludo Et al.
    Br J Pharmacol  1999;126:1025
  40. Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
    Authors: Ruiz and Tejerina
    Br J Pharmacol  1998;125:186
  41. No evidence for a significant non-nitrergic, hyperpolarising factor contribution to field stimulation-induced relaxation of the mouse anococcygeus.
    Authors: Fonseca Et al.
    Br J Pharmacol  1998;124:524
  42. Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries.
    Authors: Prieto Et al.
    Br J Pharmacol  1998;123:1609
  43. In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
    Authors: Fedele Et al.
    Br J Pharmacol  1996;119:590
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