Catalog # Availability Size / Price Qty
ODQ | CAS No. 41443-28-1 | Additional NOS Inhibitors
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Description: Selective inhibitor of NO-sensitive guanylyl cyclase

Chemical Name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Purity: ≥99%

Product Details
Citations (48)

Biological Activity

ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.

Technical Data

Soluble to 20 mM in ethanol with gentle warming and to 100 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ODQ

The citations listed below are publications that use Tocris products. Selected citations for ODQ include:

48 Citations: Showing 1 - 10

  1. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu.
    Authors: Cameron
    Sci Rep  2017;7(1):10578
  2. Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP-PKG-KATP Channel Signaling Pathway.
    Authors: Manchope Et al.
    PLoS One  2016;11:e0153015
  3. Protein kinase G-regulated production of H2S governs oxygen sensing.
    Authors: Yuan Et al.
    Sci Signal  2015;8:ra37
  4. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Braz J Med Biol Res  2015;63:383
  5. Central release of nitric oxide mediates antinociception induced by aerobic exercise.
    Authors: Galdino Et al.
    Proc Natl Acad Sci U S A  2015;48:790
  6. Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
    Authors: Padovan-Neto Et al.
    Mol Cell Neurosci  2015;35:5781
  7. Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.
    Authors: Wallace Et al.
    Proc Natl Acad Sci U S A  2015;3
  8. NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
    Authors: Bice Et al.
    Cardiovasc Res  2014;101:220
  9. Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats.
    Authors: Ho Et al.
    Cardiovasc Diabetol  2013;12:99
  10. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
    Authors: Fakira Et al.
    Glia  2012;51:22
  11. Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism.
    Authors: Tseng Et al.
    PLoS One  2011;6:e27187
  12. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
    Authors: Chester Et al.
    J Neurosci  2011;301:L755
  13. Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks.
    Authors: Moonen and Villamor
    J Comp Physiol B  2011;181:1063
  14. Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
    Authors: Harnek Et al.
    Exp Mol Med  2011;11:30
  15. Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide.
    Authors: Yoo Et al.
    J Korean Med Sci  2010;25:1411
  16. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  17. Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
    Authors: Suri Et al.
    Br J Pharmacol  2010;159:566
  18. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.
    Authors: Chester Et al.
    Am J Physiol Lung Cell Mol Physiol  2009;297:L318
  19. Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
    Authors: Hoffmann Et al.
    Br J Pharmacol  2009;157:781
  20. Modulation of inhibitory activity by nitric oxide in the thalamus.
    Authors: Yang
    J Neurophysiol  2007;97:3386
  21. Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS.
    Authors: Anselm Et al.
    Cardiovasc Res  2007;73:404
  22. Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors.
    Authors: Ågren Et al.
    Am J Physiol Regul Integr Comp Physiol  2007;292:R485
  23. Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities.
    Authors: Dalsgaard Et al.
    Am J Physiol Heart Circ Physiol  2007;292:H3072
  24. Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors.
    Authors: Makara Et al.
    J Neurosci  2007;27:10211
  25. Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction.
    Authors: Newman Et al.
    Eur J Neurosci  2007;25:1619
  26. Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery.
    Authors: McNeish Et al.
    BMC Cardiovasc Disord  2006;37:1277
  27. Anaphylactic shock depends on PI3K and eNOS-derived NO.
    Authors: Cauwels Et al.
    J Clin Invest  2006;116:2244
  28. Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells.
    Authors: Namkoong Et al.
    J Pharmacol Exp Ther  2005;37:588
  29. Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
    Authors: Sachs Et al.
    Proc Natl Acad Sci U S A  2004;101:3680
  30. Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery.
    Authors: Tsang Et al.
    Br J Pharmacol  2003;138:453
  31. Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
    Authors: Cirino Et al.
    Am J Physiol Lung Cell Mol Physiol  2003;100:5531
  32. Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life.
    Authors: Villamor Et al.
    Am J Physiol Regul Integr Comp Physiol  2002;282:R917
  33. Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
    Authors: Bellamy and Garthwaite
    Br J Pharmacol  2002;136:95
  34. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
    Authors: Stanford Et al.
    Br J Pharmacol  2001;133:825
  35. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.
    Authors: Hedlund Et al.
    Physiol Rep  2000;97:2349
  36. Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Stroke  2000;97:11593
  37. A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle.
    Authors: Haynes
    Br J Pharmacol  2000;130:685
  38. Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter.
    Authors: Mundey Et al.
    Br J Pharmacol  2000;130:489
  39. Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus.
    Authors: Dick Et al.
    Br J Pharmacol  2000;129:751
  40. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.
    Authors: Aszódi Et al.
    EMBO J  1999;18:37
  41. Deficiency in myocardial NO biosignalling after cardiop. arrest: mechanisms and contribution to post-storage mechanical dysfunction.
    Authors: Rach Et al.
    Br J Pharmacol  1999;128:891
  42. PF9404C, a new slow NO donor with beta receptor blocking properties.
    Authors: Villarroya Et al.
    Br J Pharmacol  1999;128:1713
  43. Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta.
    Authors: Pérez-Vizcaíno Et al.
    Br J Pharmacol  1999;128:1419
  44. Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta.
    Authors: Cogolludo Et al.
    Br J Pharmacol  1999;126:1025
  45. Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
    Authors: Ruiz and Tejerina
    Br J Pharmacol  1998;125:186
  46. No evidence for a significant non-nitrergic, hyperpolarising factor contribution to field stimulation-induced relaxation of the mouse anococcygeus.
    Authors: Fonseca Et al.
    Br J Pharmacol  1998;124:524
  47. Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries.
    Authors: Prieto Et al.
    Br J Pharmacol  1998;123:1609
  48. In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
    Authors: Fedele Et al.
    Br J Pharmacol  1996;119:590


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