Catalog Number: 0880
Chemical Name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Biological Activity
A potent and selective inhibitor of NO-sensitive guanylyl cyclase.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.
    Boulton et al.
    Neuroscience, 1995;69:699
  2. In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
    Fedele et al.
    Br.J.Pharmacol., 1996;119:590
  3. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
    Garthwaite et al.
    Mol.Pharmacol., 1995;48:184
  4. Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.
    Hwang et al.
    Br.J.Pharmacol., 1998;125:1158

The citations listed below are publications that use Tocris products. Selected citations for ODQ include:

30 Citations: Showing 1 - 10
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  1. Protein kinase G-regulated production of H2S governs oxygen sensing.
    Authors: Yuan Et al.
    Sci Signal 2015;8:ra37
  2. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Braz J Med Biol Res 2015;63:383
  3. Central release of nitric oxide mediates antinociception induced by aerobic exercise.
    Authors: Galdino Et al.
    Proc Natl Acad Sci U S A 2015;48:790
  4. Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
    Authors: Padovan-Neto Et al.
    Mol Cell Neurosci 2015;35:5781
  5. Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.
    Authors: Wallace Et al.
    Proc Natl Acad Sci U S A 2015;3
  6. NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
    Authors: Bice Et al.
    Cardiovasc Res 2014;101:220
  7. Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats.
    Authors: Ho Et al.
    Cardiovasc Diabetol 2013;12:99
  8. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
    Authors: Fakira Et al.
    Glia 2012;51:22
  9. Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism.
    Authors: Tseng Et al.
    PLoS One 2011;6:e27187
  10. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
    Authors: Chester Et al.
    J Neurosci 2011;301:L755
  11. Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
    Authors: Harnek Et al.
    Exp Mol Med 2011;11:30
  12. Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide.
    Authors: Yoo Et al.
    J Korean Med Sci 2010;25:1411
  13. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.
    Authors: Chester Et al.
    Am J Physiol Lung Cell Mol Physiol 2009;297:L318
  14. Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
    Authors: Hoffmann Et al.
    Br J Pharmacol 2009;157:781
  15. Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS.
    Authors: Anselm Et al.
    Cardiovasc Res 2007;73:404
  16. Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities.
    Authors: Dalsgaard Et al.
    Am J Physiol Heart Circ Physiol 2007;292:H3072
  17. Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction.
    Authors: Newman Et al.
    Eur J Neurosci 2007;25:1619
  18. Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery.
    Authors: McNeish Et al.
    BMC Cardiovasc Disord 2006;37:1277
  19. Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells.
    Authors: Namkoong Et al.
    J Pharmacol Exp Ther 2005;37:588
  20. Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
    Authors: Sachs Et al.
    Proc Natl Acad Sci U S A 2004;101:3680
  21. Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
    Authors: Cirino Et al.
    Am J Physiol Lung Cell Mol Physiol 2003;100:5531
  22. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.
    Authors: Hedlund Et al.
    Physiol Rep 2000;97:2349
  23. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Stroke 2000;97:11593
  24. Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus.
    Authors: Dick Et al.
    Br J Pharmacol 2000;129:751
  25. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.
    Authors: Aszódi Et al.
    EMBO J 1999;18:37
  26. PF9404C, a new slow NO donor with beta receptor blocking properties.
    Authors: Villarroya Et al.
    Br J Pharmacol 1999;128:1713
  27. Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta.
    Authors: Pérez-Vizcaíno Et al.
    Br J Pharmacol 1999;128:1419
  28. Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta.
    Authors: Cogolludo Et al.
    Br J Pharmacol 1999;126:1025
  29. Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
    Authors: Ruiz and Tejerina
    Br J Pharmacol 1998;125:186
  30. Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries.
    Authors: Prieto Et al.
    Br J Pharmacol 1998;123:1609
Expand to show all 30 Citations

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