Chemical Name:(3β)-3-Hydroxyolean-12-en-28-oic acid
Biological Activity GPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective.
Soluble to 20 mM in DMSO with gentle warming
Store at +4°C
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