Chemical Name: (3β)-3-Hydroxyolean-12-en-28-oic acid
Biological ActivityGPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Genet et al.
Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling.
Mu et al.
Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes.
Castellano et al.
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