Olomoucine

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
   Jorda et al.
   J.Med.Chem., 2018;61:9105
3. The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity.
   Alessi et al.
   Exp.Cell.Res., 1998;245:8
4. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.
   Abraham et al.
   Biol.Cell, 1995;83:105
5. Inhibition of cyclin-dependent kinases by purine analogues.
   Vesely et al.
   Eur.J.Biochem., 1994;224:771

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