Catalog Number: 1284
Chemical Name: 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
Biological Activity
Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM)� and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in ethanol
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.
    Abraham et al.
    Biol.Cell, 1995;83:105
  2. The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity.
    Alessi et al.
    Exp.Cell.Res., 1998;245:8
  3. Inhibition of cyclin-dependent kinases by purine analogues.
    Vesely et al.
    Eur.J.Biochem., 1994;224:771

The citations listed below are publications that use Tocris products. Selected citations for Olomoucine include:

Showing Results 1 - 1 of 1

  1. Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells.
    Authors: Cannon Et al.
    Am J Physiol Endocrinol Metab
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