Oridonin

Key Product Details

Product Description

Oridonin is a high affinity NLRP3 inflammasome inhibitor (K_d = 52.5 nM). Forms covalent bind within NACHT domain and blocks interaction of NLRP3 with NEK7 to inhibit assembly and activation of inflammasome. Inhibits glial activation, decreases inflammatory cytokine release, attenuates synaptic loss and improves behavioural deficits in Aβ1-42 treated mice. Also displays anti-cancer properties in various cancer cell lines.

Product Specifications for Oridonin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Oridonin

The following data is based on the product molecular weight 364.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yao Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells. Cell Death Dis. 2017 PMID: 28230866
• Wang Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma. Eur.J.Pharmacol. 2017 PMID: 28935563
• Wang Oridonin attenuates synaptic loss and cognitive deficits in an Aβ1-42-induced mouse model of Alzheimer's disease. PLoS One 2016 PMID: 26974541
• He Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat.Commun. 2018 PMID: 29959312
• Wang Oridonin attenuates Aβ1-42-induced neuroinflammation and inhibits NF-κB pathway. PLoS One 2014 PMID: 25121593

Product Documents for Oridonin