Oridonin

Catalog # Availability Size / Price Qty
6924/5
6924/25
Inflammasomes Inhibitors Small Molecule
1 Image
Description: High affinity NLRP3 inflammasome inhibitor

Chemical Name: 7α,20-Epoxy-1α,6β,7,14-tetrahydroxykaur-16-en-15-one

Purity: ≥98%

Product Details
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Biological Activity

High affinity NLRP3 inflammasome inhibitor (Kd = 52.5 nM). Forms covalent bind within NACHT domain and blocks interaction of NLRP3 with NEK7 to inhibit assembly and activation of inflammasome. Inhibits glial activation, decreases inflammatory cytokine release, attenuates synaptic loss and improves behavioural deficits in Aβ1-42 treated mice. Also displays anti-cancer properties in various cancer cell lines.

Technical Data

M.Wt:
364.44
Formula:
C20H28O6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
28957-04-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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