Chemical Name: 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
Biological ActivitySelective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Chauhan et al.
Cancer Cell., 2012;22:345
Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47.
Weinstock et al.
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