P005091

Catalog # Availability Size / Price Qty
4733/10
4733/50
Deubiquitinating Enzyme Inhibitors Small Molecule
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Description: USP7 inhibitor

Chemical Name: 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone

Purity: ≥99%

Product Details
Reviews

Biological Activity

Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.

Technical Data

M.Wt:
348.22
Formula:
C12H7Cl2NO3S2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
882257-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47.
    Weinstock et al.
    J.Med.Chem., 2012;3:789
  2. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes borte. resistance.
    Chauhan et al.
    Cancer Cell., 2012;22:345

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