P005091

Catalog # Availability Size / Price Qty
4733/10
4733/50
Cat.No. 4733 - P005091 | C12H7Cl2NO3S2 | CAS No. 882257-11-6
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Description: USP7 inhibitor

Chemical Name: 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone

Product Details
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Biological Activity

Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.

Technical Data

Formula:
C12H7Cl2NO3S2
Solubility:
Soluble to 10 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
882257-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
    Chauhan et al.
    Cancer Cell., 2012;22:345
  2. Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47.
    Weinstock et al.
    J.Med.Chem., 2012;3:789

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