Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50
= 4.2 μ
M). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo
Soluble to 10 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Chauhan et al.
Cancer Cell., 2012;22:345
Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47.
Weinstock et al.