p73 Antibody - C-terminus - BSA Free

Novus Biologicals | Catalog # NBP3-30843

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
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Product Specifications

Immunogen

GST-fused recombinant protein derived from the C terminal of the p73 protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for p73 Antibody - C-terminus - BSA Free

p73 Antibody - C-terminus

Western Blot: p73 Antibody - C-terminus [NBP3-30843] -

Western Blot: p73 Antibody - C-terminus [NBP3-30843] - Western blot analysis using p73 alpha antibody on H1299 cells transfected with p73 alpha protein.

Applications for p73 Antibody - C-terminus - BSA Free

Application
Recommended Usage

Western Blot

: 5-10 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Ammonium sulfate precipitation

Formulation

Phosphate buffered saline

Format

BSA Free

Preservative

0.08% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: p73

p73 is a transcription factor that shares a significant amino acid identity with p53 and p63 (1). p73 and p63 can both activate p53-responsive genes and induce apoptosis upon over expression (2) Unlike p53, p73 is not induced by DNA damage and is not a target for inactivation by viral oncoproteins (3). Similar to p63, p73 has an additional coding region in the C-terminus (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (alpha, beta, and gamma) (4). Activation of p73 requires the presence of functional c-Abl. It has also be found that mutant p53 can bind to and inactivate p73 (5).

Long Name

Tumor Protein p73

Alternate Names

TP73

Gene Symbol

TP73

Additional p73 Products

Product Documents for p73 Antibody - C-terminus - BSA Free

Certificate of Analysis

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Product Specific Notices for p73 Antibody - C-terminus - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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