Parthenolide

  ( 1 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0610
Chemical Name:[1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Product Details
Citations (1)
Supplemental Products
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Biological Activity
The active principle of feverfew (Chrysanthemum parthenium). Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits activation of NF-κB, and generation of leukotriene B4 and thromboxane B2.
Technical Data
  • M.Wt:
    248.32
  • Formula:
    C15H20O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    20554-84-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Parthenolide include:

1 Citations: Showing 1 - 1

  1. Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
    Authors: Lee Et al.
    Anesth Analg  2016;7:11322

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Average Rating: 5 (Based on 1 review)

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We have 1 review tested in 1 species: Other.

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  Excellent
  Other One Pagan 01/10/2018
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Summary

Species Other
Pub Med ID 22451007, 21886554, 21878350, 18275955, 18222535

Other Experimental Details

Other Experimental Details I have used Tocris’ Parthenolide (Cat. No. 0610) for a few years in my research program searching for behavioral antagonists of cocaine. This research has resulted in 5 peer-reviewed papers and the discovery story is included in a chapter of my book The First Brain: The Neuroscience of Planarians and in a review paper (shown in the figure). There are at least 4 more papers in preparation and the project is still going strong. In the initial phases of my project, I evaluated several suppliers of parthenolide and Tocris’ offering consistently came ahead in terms of customer service and compound purity, and I do not intend to change suppliers. I recommend this product and the company without reservation.

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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