Catalog Number: 0610
Chemical Name: [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Biological Activity
The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B4 and thromboxane B2.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro.
    Groenewegen and Heptinstall
    J.Pharm.Pharmacol., 1990;42:553
  2. Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit.
    Heptinstall et al.
    J.Pharm.Pharmacol., 1986;38:709
  3. Randomized double-blind placebo controlled trial of feverfew in migraine prevention.
    Murphy et al.
    Lancet, 1988;2:189
  4. Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components.
    Sumner et al.
    Biochem.Pharmacol., 1992;43:2313

The citations listed below are publications that use Tocris products. Selected citations for Parthenolide include:

Showing Results 1 - 1 of 1

  1. Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
    Authors: Lee Et al.
    Anesth Analg
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