Chemical Name: [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Biological ActivityThe active principle of feverfew (Chrysanthemum parthenium). Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits activation of NF-κB, and generation of leukotriene B4 and thromboxane B2.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β.
Hehner et al.
A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro.
Groenewegen and Heptinstall
Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit.
Heptinstall et al.
Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components.
Sumner et al.
Citations for Parthenolide
The citations listed below are publications that use Tocris products. Selected citations for Parthenolide include:
2 Citations: Showing 1 - 2
Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
Authors: Lee Et al.
Anesth Analg 2016;7:11322
Parthenolide Blocks Cocaine's Effect on Spontaneous Firing Activity of DArgic Neurons in the Ventral Tegmental Area.
Authors: Schwarz Et al.
Curr Neuropharmacol 2011;9:17
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Behavioral evaluation of antagonistic effects of parthenolide on cocaine effects in planarians