The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B4
and thromboxane B2
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A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro.
Groenewegen and Heptinstall
Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit.
Heptinstall et al.
Randomized double-blind placebo controlled trial of feverfew in migraine prevention.
Murphy et al.
Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components.
Sumner et al.
The citations listed below are publications that use Tocris products. Selected citations for Parthenolide include:
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