Chemical Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Biological ActivityPotent MEK1 and MEK2 inhibitor. Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Enhances generation of induced pluripotent stem cells (iPSCs). Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A chemical platform for improved induction of human iPSCs.
Lin et al.
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
Barrett et al.
Growth-inhibitor and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations.
Ciuffreda et al.
The biological profile of PD 0325901: a second generation analog of CI-1040 with improved pharmaceutical potential.
Sebolt-Leopold et al.
Proc.Amer.Assoc.Cancer Res., 2004;45:925
Citations for PD 0325901
The citations listed below are publications that use Tocris products. Selected citations for PD 0325901 include:
16 Citations: Showing 1 - 10
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Nat Commun 2018;9(1):475
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Nat Med 2018;24(5):647
CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
Authors: Liu Et al.
Cell Stem Cell. 2018;22:252
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.
Authors: Gupta Et al.
Mol Cell 2017;65:999
Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways.
Authors: Jullien Et al.
Mol Cell 2017;65:873
The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation.
Authors: Zawily Et al.
Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia.
Authors: Oliveira Et al.
Stem Cells 2016;13:11
Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors.
Authors: Maza Et al.
Nat Biotechnol 2015;33:769
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Authors: Mattis Et al.
PLoS One 2015;24:3257
Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines.
Authors: Holland Et al.
J Cancer Res Clin Oncol 2015;141:615
Functional annotation of native enhancers with a Cas9-histone demethylase fusion.
Authors: Kearns Et al.
Nat Methods 2015;12:401
The bimodally expressed microRNA miR-142 gates exit from pluripotency.
Authors: Sladitschek and Neveu
J Neuroinflammation 2015;11:850
Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells' Transcription Factors.
Authors: Solari Et al.
Mol Syst Biol 2015;10:e0144336
A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence.
Authors: Muthusamy Et al.
Stem Cell Reports 2014;3:169
Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage.
Authors: Denham Et al.
Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states.
Authors: Cho Et al.
Cancer Biol Ther 2012;139:2866
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Mouse ES cells in 2i remain to be in the naive pluripotent state while cells in -2i for 48 hours exit naive pluripotency
Primary lung endothelial cells were pretreated with various concentrations of PD 0325901 for 30 minutes prior to the treatment of IL1b (1ng/ml).
24 hours later, cell was lyzed and analyzed by western blot. Lane 1: PBS controlLane 2: + PD 0326901 100nMLane 3: + PD 0326901 10nM