PD 0325901

Catalog # Availability Size / Price Qty
4192/10
4192/50
Cat.No. 4192 - PD 0325901 | C16H14F3IN2O4 | CAS No. 391210-10-9
1 Image
Description: Potent inhibitor of MEK1/2
Alternative Names: PD325901

Chemical Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

Purity: ≥99%

Product Details
Citations (16)
Reviews (2)

Biological Activity

Potent MEK1 and MEK2 inhibitor. Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Enhances generation of induced pluripotent stem cells (iPSCs). Orally active.

Technical Data

M.Wt:
482.19
Formula:
C16H14F3IN2O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
391210-10-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. A chemical platform for improved induction of human iPSCs.
    Lin et al.
    Nat.Methods., 2009;6:805
  2. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
    Barrett et al.
    Bioorg.Med.Chem.Lett., 2008;18:6501
  3. Growth-inhibitor and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations.
    Ciuffreda et al.
    Neoplasia, 2009;11:720
  4. The biological profile of PD 0325901: a second generation analog of CI-1040 with improved pharmaceutical potential.
    Sebolt-Leopold et al.
    Proc.Amer.Assoc.Cancer Res., 2004;45:925

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for PD 0325901

The citations listed below are publications that use Tocris products. Selected citations for PD 0325901 include:

16 Citations: Showing 1 - 10

  1. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475
  2. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
    Authors: Wang
    Nat Med  2018;24(5):647
  3. CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
    Authors: Liu Et al.
    Cell Stem Cell.  2018;22:252
  4. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.
    Authors: Gupta Et al.
    Mol Cell  2017;65:999
  5. Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways.
    Authors: Jullien Et al.
    Mol Cell  2017;65:873
  6. The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation.
    Authors: Zawily Et al.
    Oncotarget  2016;7:77865
  7. Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia.
    Authors: Oliveira Et al.
    Stem Cells  2016;13:11
  8. Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors.
    Authors: Maza Et al.
    Nat Biotechnol  2015;33:769
  9. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
    Authors: Mattis Et al.
    PLoS One  2015;24:3257
  10. Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines.
    Authors: Holland Et al.
    J Cancer Res Clin Oncol  2015;141:615

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PD 0325901

Average Rating: 5 (Based on 2 Reviews)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used PD 0325901?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Mmaintenance of naive pluripotency in 2i
By Megha PB on 07/18/2018
Species: Mouse

Mouse ES cells in 2i remain to be in the naive pluripotent state while cells in -2i for 48 hours exit naive pluripotency


Great inhibitor for ERK signaling
By Anonymous on 12/08/2017
Species: Mouse

Primary lung endothelial cells were pretreated with various concentrations of PD 0325901 for 30 minutes prior to the treatment of IL1b (1ng/ml).

24 hours later, cell was lyzed and analyzed by western blot. Lane 1: PBS controlLane 2: + PD 0326901 100nMLane 3: + PD 0326901 10nM


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.