Chemical Name: 3-Oxo-L-gulofuranolactone
Biological ActivityL-Ascorbic acid is an inhibitor of Cav3.2 channels (IC50 = 6.5 μM); displays no effect on Cav3.1 or Cav3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Commonly used antifade reagent in live cell microscopy. Naturally occurring antioxidant.
For more information about how L-Ascorbic acid may be used, see our protocol:Highly Efficient Generation of CiPSCs from MEFs
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Vitamin C as an antioxidant: evaluation of its role in disease prevention.
Padayatty et al.
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.
Nelson et al.
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.
Esteban et al.
Cell Stem Cell, 2010;6:71
Mechanisms and advancement of antifading agents for fluorescence microscopy and single-molecule spectroscopy.
Cordes et al.
Citations for L-Ascorbic acid
The citations listed below are publications that use Tocris products. Selected citations for L-Ascorbic acid include:
6 Citations: Showing 1 - 6
Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells.
Authors: Tristan Et al.
Stem Cell Rep. 2021;16:3076
The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
Authors: Wang Et al.
J Clin Invest 2018;128:3319
Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages.
Authors: Shahraz Et al.
Cell Rep 2015;5:16800
Optimization of a cisp. model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status.
Authors: Guindon Et al.
Mol Pain 2014;10:56
Generation of integration-free and region-specific neural progenitors from primate fibroblasts.
Authors: Lu Et al.
BMC Dev Biol 2013;3:1580
Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199.
Authors: Yeligar Et al.
J Immunol 2009;183:5232
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Homemade media for iPSC culture containing L-Ascorbic Acid at a final concentration of 50 ug/ml gives consistent results. Image shows Mapx-5 cell line, containing collagen IV mutations from an Alport Syndrome patient.