L-Ascorbic acid

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L-Ascorbic acid | CAS No. 50-81-7 | Compounds for Induced Pluripotent Stem Cells
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Description: Enhances the generation of iPSCs; increases reprogramming efficiency
Alternative Names: L-Ascorbate, Vitamin C

Chemical Name: 3-Oxo-L-gulofuranolactone

Purity: ≥99%

Product Details
Citations (6)
Reviews (2)

Biological Activity

L-Ascorbic acid is an inhibitor of Cav3.2 channels (IC50 = 6.5 μM); displays no effect on Cav3.1 or Cav3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Commonly used antifade reagent in live cell microscopy. Naturally occurring antioxidant.

For more information about how L-Ascorbic acid may be used, see our protocol:

Highly Efficient Generation of CiPSCs from MEFs

Technical Data

Soluble to 500 mM in water and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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The hiPSCs were maintained with Essential 8 Flex Medium with L-Ascorbic acid
By Anonymous on 02/08/2020
Application: Species: Human

0.2 mM

PMID: 29939162

iPSC media
By Pinyuan Tian on 07/17/2018
Application: Species: Human

Homemade media for iPSC culture containing L-Ascorbic Acid at a final concentration of 50 ug/ml gives consistent results. Image shows Mapx-5 cell line, containing collagen IV mutations from an Alport Syndrome patient.

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