Inhibitor of Cav
3.2 channels (IC50
= 6.5 μ
M); displays no effect on Cav
3.1 or Cav
3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Naturally occurring antioxidant.
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All Tocris products are intended for laboratory research use only.
Vitamin C as an antioxidant: evaluation of its role in disease prevention.
Padayatty et al.
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.
Nelson et al.
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.
Esteban et al.
Cell Stem Cell, 2010;6:71
The citations listed below are publications that use Tocris products. Selected citations for L-Ascorbic acid include:
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