Catalog Number: 4055
Alternate Names: L-Ascorbate, Vitamin C
Chemical Name: 3-Oxo-L-gulofuranolactone
Biological Activity
Inhibitor of Cav3.2 channels (IC50 = 6.5 μM); displays no effect on Cav3.1 or Cav3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Naturally occurring antioxidant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 500 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Vitamin C as an antioxidant: evaluation of its role in disease prevention.
    Padayatty et al.
    J.Am.Coll.Nutr., 2003;22:18
  2. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.
    Nelson et al.
    J.Neurosci., 2007;27:12577
  3. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.
    Esteban et al.
    Cell Stem Cell, 2010;6:71

The citations listed below are publications that use Tocris products. Selected citations for L-Ascorbic acid include:

3 Citations: Showing 1 - 3
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  1. Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages.
    Authors: Shahraz Et al.
    Cell Rep 2015;5:16800
  2. Generation of integration-free and region-specific neural progenitors from primate fibroblasts.
    Authors: Lu Et al.
    BMC Dev Biol 2013;3:1580
  3. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199.
    Authors: Yeligar Et al.
    J Immunol 2009;183:5232

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