PD 166285 dihydrochloride

Catalog # Availability Size / Price Qty
3785/1
3785/10
PD 166285 dihydrochloride | CAS No. 212391-63-4 | Src Family Kinase Inhibitors
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Description: Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

Chemical Name: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.

Technical Data

M.Wt:
585.35
Formula:
C26H27Cl2N5O2.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
212391-63-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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Citation for PD 166285 dihydrochloride

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