PD 166285 dihydrochloride

Key Product Details

Product Description

PD 166285 dihydrochloride is a potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC₅₀ values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G₂ checkpoint.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PD 166285 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PD 166285 dihydrochloride

The following data is based on the product molecular weight 585.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.71 mL	8.54 mL	17.08 mL
5 mM	0.34 mL	1.71 mL	3.42 mL
10 mM	0.17 mL	0.85 mL	1.71 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Wang Radiosensitization of p53 mutant cells by PD0166285, a novel G₂ checkpoint abrogator. Cancer Res. 2001 PMID: 11719452
• Hashimoto Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 2006 PMID: 17177986
• Panek In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J.Pharmacol.Exp.Ther. 1997 PMID: 9400019

Product Documents for PD 166285 dihydrochloride