Catalog Number: 3785
Chemical Name: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
Biological Activity
Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.
Technical Data
  • M.Wt:
    585.35
  • Formula:
    C26H27Cl2N5O2.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    212391-63-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.
    Panek et al.
    J.Pharmacol.Exp.Ther., 1997;283:1433
  2. Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator.
    Wang et al.
    Cancer Res., 2001;61:8211
  3. Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line.
    Hashimoto et al.
    BMC Cancer, 2006;6:292
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 166285 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes.
    Authors: Gaffré Et al.
    Toxicol Lett 2011;138:3735

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