PD 166285 dihydrochloride
Chemical Name: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
Biological ActivityPD 166285 dihydrochloride is a potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.
Panek et al.
Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator.
Wang et al.
Cancer Res., 2001;61:8211
Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line.
Hashimoto et al.
BMC Cancer, 2006;6:292
Citation for PD 166285 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PD 166285 dihydrochloride include:
1 Citation: Showing 1 - 1
A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes.
Authors: Gaffré Et al.
Toxicol Lett 2011;138:3735
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