PD 166285 dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:3785
Chemical Name:6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.
Technical Data
  • M.Wt:
    585.35
  • Formula:
    C26H27Cl2N5O2.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    212391-63-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 166285 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes.
    Authors: Gaffré Et al.
    Toxicol Lett  2011;138:3735

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