PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
Human PDGF R beta (AAA36427) VersaClone cDNA
R&D Systems | Catalog # RDC0396
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: PDGF R beta
Long Name
Platelet-derived Growth Factor Receptor beta
Alternate Names
CD140b, PDGFRB
Gene Symbol
PDGFRB
UniProt
Additional PDGF R beta Products
Product Documents for Human PDGF R beta (AAA36427) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human PDGF R beta (AAA36427) VersaClone cDNA
For research use only
Related Research Areas
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