Penitrem A

Tocris Bioscience | Catalog # 4617

Potent and selective KCa1.1 (BK) channel blocker
Tocris Bioscience
Discontinued Product
4617 has been discontinued. View all Ca2+-Activated Potassium Channel Blockers products.

Key Product Details

Description

Potent and selective KCa1.1 (BK) channel blocker
View all Ca2+-Activated Potassium Channel Blockers »

Product Description

Penitrem A is a potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing α subunits only, and those containing α and β1 respectively). Displays no effect on native delayed rectifier K+ and KATP currents, or cloned KV1.5 channels. Blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo.

Product Specifications for Penitrem A

Molecular Weight

634.20

Formula

C37H44ClNO6

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol

CAS Number

12627-35-9

PubChem ID

6610243

InChI Key

JDUWHZOLEDOQSR-JKPSMKLGSA-N

SMILES

O[C@H]9[C@@H]([C@](C)=C)O[C@@]([C@@]%108[C@@H]9O%10)([H])CC[C@]([C@@]8(O)CC7)(C)[C@@]([C@]7([H])[C@@H]4OC(C)(C)[C@]([H])5C6)(C)C3=C4C1=C(N3)C=C(Cl)C2=C1[C@@]5(O)[C@@]6([H])C(C2)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.34 10

Preparing Stock Solutions for Penitrem A

The following data is based on the product molecular weight 634.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.77 mL 78.84 mL 157.68 mL
0.5 mM 3.15 mL 15.77 mL 31.54 mL
1 mM 1.58 mL 7.88 mL 15.77 mL
5 mM 0.32 mL 1.58 mL 3.15 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for Penitrem A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Penitrem A

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Penitrem A (1)

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  • Penitrem A as a selective BK blocker worked ideally
    Name: Sadequl Islam
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK 293
    Verified Customer | Posted 10/13/2018
    Product used to understand BK channel blocking activity on HEK 293 cell line.The cell line expresses brain alpha subunits of BK channel. Showed blocking activity on electrophysiological tests. Product worked ideally and would definitely worth buying.
    Penitrem A 4617

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