Potent and selective blocker of BKCa
1.1) channels (IC50
values are 6.4 and 64.4 nM for BKCa
channels containing α
subunits only, and those containing α
1 respectively). Displays no effect on native delayed rectifier K+
currents, or cloned KV
1.5 channels. Blocks BKCa
channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro
and increase total peripheral resistance in vivo
Soluble to 10 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels.
Knaus et al.
Penitrem A as a tool for understanding the role of large conductance Ca2+/voltage-sensitive K+ channels in vascular function.
Asano et al.
The citations listed below are publications that use Tocris products. Selected citations for Penitrem A include:
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