selective agonist. IC50
values are 0.11 and 1050 nM for inhibition of 125
I-PYY binding to Y2
receptors respectively. Inhibits food intake and reduces weight gain in vivo
. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Gut hormone PYY3-36 physiologically inhibits food intake.
Batterham et al.
Primary structures of PYY, [Pro34]PYY and PYY-(3-36) confer different conformations and receptor selectivity.
Keire et al.
Am.J.Physiol.Gastrointest.Liver Physiol., 2000;279:G126
Characterization of blood-brain barrier permeability to PYY3-36 in the mouse.
Nonaka et al.
The citations listed below are publications that use Tocris products. Selected citations for Peptide YY (3-36) include:
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