PF 05212384

Catalog # Availability Size / Price Qty
4823/10
Cat.No. 4823 - PF 05212384 | C32H41N9O4 | CAS No. 1197160-78-3
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Description: Potent and selective dual PI 3-K/mTOR inhibitor
Alternative Names: PKI-587, Gedatolisib

Chemical Name: N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]urea

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent and selective dual inhibitor of PI 3-kinase/mTOR (IC50 values are 0.4, 1.6 and 5.4 nM for PI 3-Kα, mTOR and PI 3-Kγ respectively). Exhibits selectivity over 234 other protein kinases (IC50 >10 μM). Potently inhibits tumor cell growth in 37 different tumor cell lines (IC50 < 100 nM). Also exhibits antitumor activity in MDA-361, HCT-116, H1975 and U87MG xenograft models.

Technical Data

M.Wt:
615.73
Formula:
C32H41N9O4
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1197160-78-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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