High affinity and potent covalent EGFR kinase inhibitor (Ki
= 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC50
values are 5.8 and 6.6 nM, respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance.
Schwartz et al.