[(pF)Phe4]Nociceptin(1-13)NH2
![[(pF)Phe4]Nociceptin(1-13)NH2](https://resources.rndsystems.com/images/datasheets/structures/pf-phe4-nociceptin-1-13-nh2_1566.png "[(pF)Phe4]Nociceptin(1-13)NH2")
Description: Potent, selective nociceptin receptor agonist
Biological Activity
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo.Technical Data
M.Wt:
1399.6
Formula:
C61H99FN22O15
Sequence:
FGGFTGARKSARK
(Modifications: Phe-4 = p-fluoro-Phe, Lys-14 = C-terminal amide)
Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
380620-88-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies.
Bigoni et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2002;365:442 -
Structure-activity studies of the Phe4 residue of nociceptin(1-13)-NH2: Identification of highly potent agonists of the nociceptin/orphanin FQ receptor.
Guerrini et al.
J.Med.Chem., 2001;44:3956 -
Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 2. In vivo studies.
Rizzi et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2002;365:450
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