Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Biological ActivitySelective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Miao et al.
Citation for PIT 1
The citations listed below are publications that use Tocris products. Selected citations for PIT 1 include:
1 Citation: Showing 1 - 1
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
Authors: Juvekar Et al.
Proc Natl Acad Sci U S A 2016;113:E4338
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PIT 1
Average Rating: 5 (Based on 1 Review)
Have you used PIT 1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Induction of PAR and gamma H2ax by the PIP3-mimetic PIT1 (0-100uM)