antagonist. Blocks the binding of PIP3
to the pleckstrin homology (PH) domain of Akt (IC50
= 31.03 μ
M). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3
-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo
Soluble to 75 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Miao et al.