Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Biological ActivitySelective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Miao et al.
Citation for PIT 1
The citations listed below are publications that use Tocris products. Selected citations for PIT 1 include:
1 Citation: Showing 1 - 1
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
Authors: Juvekar Et al.
Proc Natl Acad Sci U S A 2016;113:E4338
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