Chemical Name: 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione
Biological ActivityPotent and selective A1 adenosine receptor antagonist. Displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. Demonstrates greater selectivity than DPCPX (Cat. No. 0439).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antinociceptive effects of novel A2B adenosine receptor antagonists.
Abo-Salem et al.
Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones.
Weyler et al.
Citations for PSB 36
The citations listed below are publications that use Tocris products. Selected citations for PSB 36 include:
5 Citations: Showing 1 - 5
Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
Authors: Cheng Et al.
Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
Authors: Ziemlinska Et al.
PLoS One 2014;9:e88833
Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups.
Authors: Arnal Et al.
Respir Physiol Neurobiol 2013;186:73
Adenosine A(2) receptors modulate tubuloglomerular feedback.
Authors: Carlström Et al.
Am J Physiol Renal Physiol 2010;299:F412
Paraxanthine, the primary metabolite of caffeine, provides protection against DArgic cell death via stimulation of ryanodine receptor channels.
Authors: Guerreiro Et al.
Mol Pharmacol 2008;74:980
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