PSB 36

Key Product Details

Product Description

PSB 36 is a potent and selective A₁ adenosine receptor antagonist. PSB 36 displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA₁, hA_2B, rA_2A, rA₃ and hA₃ receptors respectively. PSB 36 demonstrates greater selectivity than DPCPX (Cat. No. 0439). PSB 36 reduces atrial fibrillation in rat isolated beating heart preparations.

Product Specifications for PSB 36

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PSB 36

The following data is based on the product molecular weight 386.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.94 mL	25.87 mL
5 mM	0.52 mL	2.59 mL	5.17 mL
10 mM	0.26 mL	1.29 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8567 publications citing the usage of this product.

• Weyler Improving potency, selectivity, and water solubility of adenosine A₁ receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. Chem.Med.Chem.
• Soattin Inhibition of adenosine pathway alters atrial electrophysiology and prevents atrial fibrillation. Front Physiol. 2020 PMID: 32595514
• Abo-Salem Antinociceptive effects of novel A_2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther 2004 PMID: 14563788

Product Documents for PSB 36