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PSB 36

2019 5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2019/10
2019/50
PSB 36 | CAS No. 524944-72-7 | Adenosine A1 Receptor Antagonists
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Description: Potent and selective A1 antagonist

Chemical Name: 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione

Purity: ≥99%

Product Details
Citations (5)
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Biological Activity

Potent and selective A1 adenosine receptor antagonist. Displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. Demonstrates greater selectivity than DPCPX (Cat. No. 0439).

Technical Data

M.Wt:
386.49
Formula:
C21H30N4O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
524944-72-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antinociceptive effects of novel A2B adenosine receptor antagonists.
    Abo-Salem et al.
    J.Pharmacol.Exp.Ther., 2004;308:358
  2. Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones.
    Weyler et al.
    Chem.Med.Chem., 2006;1:891

Product Datasheets

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Citations for PSB 36

The citations listed below are publications that use Tocris products. Selected citations for PSB 36 include:

5 Citations: Showing 1 - 5

  1. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
    Authors: Cheng Et al.
    Structure  2017;25:1275
  2. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
    Authors: Ziemlinska Et al.
    PLoS One  2014;9:e88833
  3. Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups.
    Authors: Arnal Et al.
    Respir Physiol Neurobiol  2013;186:73
  4. Adenosine A(2) receptors modulate tubuloglomerular feedback.
    Authors: Carlström Et al.
    Am J Physiol Renal Physiol  2010;299:F412
  5. Paraxanthine, the primary metabolite of caffeine, provides protection against DArgic cell death via stimulation of ryanodine receptor channels.
    Authors: Guerreiro Et al.
    Mol Pharmacol  2008;74:980

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VersaClone cDNA Plasmids

Mouse Adenosine A1R (NP_000665) VersaClone cDNA

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