Catalog Number: 2019
Chemical Name: 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione
Biological Activity
Potent and selective A1 adenosine receptor antagonist. Displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. Demonstrates greater selectivity than DPCPX (Cat. No. 0439).
Technical Data
  • M.Wt:
    386.49
  • Formula:
    C21H30N4O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    524944-72-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antinociceptive effects of novel A2B adenosine receptor antagonists.
    Abo-Salem et al.
    J.Pharmacol.Exp.Ther., 2004;308:358
  2. Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones.
    Weyler et al.
    Chem.Med.Chem., 2006;1:891
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PSB 36 include:

3 Citations: Showing 1 - 3
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  1. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
    Authors: Ziemlinska Et al.
    PLoS One 2014;9:e88833
  2. Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups.
    Authors: Arnal Et al.
    Respir Physiol Neurobiol 2013;186:73
  3. Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels.
    Authors: Guerreiro Et al.
    Mol Pharmacol 2008;74:980

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