Catalog Number: 0439
Chemical Name: 8-Cyclopentyl-1,3-dipropylxanthine
Biological Activity
Potent and selective A1 adenosine receptor antagonist, both in vitro and in vivo. Ki values are 3.9, 130, 50 and 4000 nM for human A1, A2A, A2B and A3 receptors respectively.
Technical Data
  • M.Wt:
    304.39
  • Formula:
    C16H24N4O2
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    102146-07-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Metabolic challenge to glia activates and adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves.
    Canals et al.
    J.Cereb.Blood Flow Metab., 2008;28:1835
  2. Adenosine receptors and their ligands.
    Klot
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  3. An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo.
    Kuan et al.
    J.Pharmacol.Exp.Ther., 1992;263:657
  4. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.
    Von der Leyen
    Naunyn Schmiedebergs Arch.Pharmacol., 1989;340:204
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DPCPX include:

34 Citations: Showing 1 - 10
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  1. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    J Inflamm (Lond) 2015;9:409
  2. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods 2015;12:661
  3. Anti-inflammatory effects of adenosine N1-oxide.
    Authors: Kohno Et al.
    Am J Physiol Lung Cell Mol Physiol 2015;12:2
  4. Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1� and A2A receptor activation.
    Authors: Cunha Et al.
    J Clin Invest 2015;11:215
  5. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Neurosci 2015;10:e0125974
  6. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
    Authors: Carlsen and Perrier
    Front Neural Circuits 2014;8:60
  7. Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
    Authors: Ruby Et al.
    Korean J Anesthesiol 2014;39:2432
  8. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
    Authors: Li Et al.
    Vis Neurosci 2014;31:237
  9. Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.
    Authors: Fuss Et al.
    Synapse 2013;67:648
  10. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.
    Authors: Augusto Et al.
    Biochim Biophys Acta 2013;33:11390
  11. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol 2012;86:10338
  12. Importance of GluA1 subunit-containing AMPA glutamate receptors for morphine state-dependency.
    Authors: Aitta-Aho Et al.
    PLoS One 2012;7:e38325
  13. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study.
    Authors: Lee Et al.
    J Cell Biol 2012;63:340
  14. GABAB receptor-positive modulators: brain region-dependent effects.
    Authors: Hensler Et al.
    J Pharmacol Exp Ther 2012;340:19
  15. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep 2012;2:285
  16. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
    Authors: Stoddart Et al.
    Chem Biol 2012;19:1105
  17. Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine.
    Authors: Lutz Et al.
    Eur Neuropsychopharmacol 2011;21:835
  18. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    Proc Natl Acad Sci U S A 2010;335:781
  19. Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
    Authors: Burbassi Et al.
    Eur J Neurosci 2010;32:1278
  20. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol 2009;47:684
  21. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
    Authors: Clark Et al.
    J Neurosci 2009;29:11237
  22. Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice.
    Authors: Yu Et al.
    Neuropsychopharmacology 2009;297:L785
  23. Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep.
    Authors: Maeda and Koos
    Purinergic Signal 2009;296:R693
  24. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
    Authors: Epperson Et al.
    Am J Physiol Cell Physiol 2009;296:C1171
  25. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation.
    Authors: Rex Et al.
    Am J Respir Crit Care Med 2009;186:85
  26. GTPgammaS incorporation in the rat brain: a study on mu-opioid receptors and CXCR4.
    Authors: Burbassi Et al.
    J Neuroimmune Pharmacol 2008;3:26
  27. Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.
    Authors: Wolk Et al.
    Am J Physiol Regul Integr Comp Physiol 2008;178:969
  28. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives.
    Authors: Bhanu Et al.
    PLoS One 2008;1782:504
  29. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.
    Authors: Eckle Et al.
    J Neurosci 2008;118:3301
  30. Characterization of AMPA receptors targeted by the climbing fiber transmitter mediating presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses.
    Authors: Satake Et al.
    J Neurosci 2006;26:2278
  31. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Front Cell Neurosci 2005;25:5502
  32. Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge.
    Authors: Kornerup Et al.
    Br J Pharmacol 2005;144:1011
  33. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci 2004;24:4530
  34. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
    Authors: Moore Et al.
    J Neurosci 2003;100:14397
Expand to show all 34 Citations

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