Catalog Number: 0439
Chemical Name: 8-Cyclopentyl-1,3-dipropylxanthine
Biological Activity
Potent and selective A1 adenosine receptor antagonist, both in vitro and in vivo. Ki values are 3.9, 130, 50 and 4000 nM for human A1, A2A, A2B and A3 receptors respectively.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Metabolic challenge to glia activates and adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves.
    Canals et al.
    J.Cereb.Blood Flow Metab., 2008;28:1835
  2. Adenosine receptors and their ligands.
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  3. An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo.
    Kuan et al.
    J.Pharmacol.Exp.Ther., 1992;263:657
  4. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.
    Von der Leyen
    Naunyn Schmiedebergs Arch.Pharmacol., 1989;340:204

The citations listed below are publications that use Tocris products. Selected citations for DPCPX include:

Showing Results 1 - 10 of 34

  1. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    J Inflamm (Lond)
  2. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods
  3. Anti-inflammatory effects of adenosine N1-oxide.
    Authors: Kohno Et al.
    Am J Physiol Lung Cell Mol Physiol
  4. Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1� and A2A receptor activation.
    Authors: Cunha Et al.
    J Clin Invest
  5. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Neurosci
  6. Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
    Authors: Carlsen and Perrier
    Front Neural Circuits
  7. Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
    Authors: Ruby Et al.
    Korean J Anesthesiol
  8. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
    Authors: Li Et al.
    Vis Neurosci
  9. Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.
    Authors: Fuss Et al.
  10. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.
    Authors: Augusto Et al.
    Biochim Biophys Acta
  11. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol
  12. Importance of GluA1 subunit-containing AMPA glutamate receptors for morphine state-dependency.
    Authors: Aitta-Aho Et al.
    PLoS One
  13. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study.
    Authors: Lee Et al.
    J Cell Biol
  14. GABAB receptor-positive modulators: brain region-dependent effects.
    Authors: Hensler Et al.
    J Pharmacol Exp Ther
  15. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep
  16. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
    Authors: Stoddart Et al.
    Chem Biol
  17. Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine.
    Authors: Lutz Et al.
    Eur Neuropsychopharmacol
  18. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    Proc Natl Acad Sci U S A
  19. Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
    Authors: Burbassi Et al.
    Eur J Neurosci
  20. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol
  21. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
    Authors: Clark Et al.
    J Neurosci
  22. Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice.
    Authors: Yu Et al.
  23. Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep.
    Authors: Maeda and Koos
    Purinergic Signal
  24. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
    Authors: Epperson Et al.
    Am J Physiol Cell Physiol
  25. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation.
    Authors: Rex Et al.
    Am J Respir Crit Care Med
  26. GTPgammaS incorporation in the rat brain: a study on mu-opioid receptors and CXCR4.
    Authors: Burbassi Et al.
    J Neuroimmune Pharmacol
  27. Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.
    Authors: Wolk Et al.
    Am J Physiol Regul Integr Comp Physiol
  28. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives.
    Authors: Bhanu Et al.
    PLoS One
  29. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.
    Authors: Eckle Et al.
    J Neurosci
  30. Characterization of AMPA receptors targeted by the climbing fiber transmitter mediating presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses.
    Authors: Satake Et al.
    J Neurosci
  31. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Front Cell Neurosci
  32. Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge.
    Authors: Kornerup Et al.
    Br J Pharmacol
  33. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci
  34. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
    Authors: Moore Et al.
    J Neurosci
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