Chemical Name: 8-Cyclopentyl-1,3-dipropylxanthine
Biological ActivityPotent and selective A1 adenosine receptor antagonist, both in vitro and in vivo. Ki values are 3.9, 130, 50 and 4000 nM for human A1, A2A, A2B and A3 receptors respectively.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Metabolic challenge to glia activates and adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves.
Canals et al.
J.Cereb.Blood Flow Metab., 2008;28:1835
Adenosine receptors and their ligands.
Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo.
Kuan et al.
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.
Von der Leyen
Naunyn Schmiedebergs Arch.Pharmacol., 1989;340:204
Citations for DPCPX
The citations listed below are publications that use Tocris products. Selected citations for DPCPX include:
45 Citations: Showing 1 - 10
Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
Authors: Liu Et al.
Brain Res. 2018;1700:47
Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
Authors: Angelantonio Et al.
J Inflamm (Lond) 2015;9:409
Application of BRET to monitor ligand binding to GPCRs.
Authors: Stoddart Et al.
Nat Methods 2015;12:661
Anti-inflammatory effects of adenosine N1-oxide.
Authors: Kohno Et al.
Am J Physiol Lung Cell Mol Physiol 2015;12:2
Creatine, similarly to KA, affords antidepressant-like effects in the tail suspension test via adenosine A1� and A2A receptor activation.
Authors: Cunha Et al.
J Clin Invest 2015;11:215
Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
Authors: Dobson Et al.
J Neurosci 2015;10:e0125974
Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
Authors: Carlsen and Perrier
Front Neural Circuits 2014;8:60
Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
Authors: Ruby Et al.
Korean J Anesthesiol 2014;39:2432
Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
Authors: Li Et al.
Vis Neurosci 2014;31:237
Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.
Authors: Diógenes Et al.
Cereb Cortex 2014;24:67
The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A 2A receptors.
Authors: Kaster Et al.
Purinergic Signal 2013;9:481
Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.
Authors: Fuss Et al.
Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.
Authors: Augusto Et al.
Biochim Biophys Acta 2013;33:11390
Fractalkine (CX3CL1) enhances hippocampal N-MthD.-aspartate receptor (NMDAR) function via D-serine and adenosine receptor type A2 (A2AR) activity.
Authors: Scianni Et al.
J Neuroinflammation 2013;10:108
Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
Authors: Kan Et al.
J Virol 2012;86:10338
Importance of GluA1 subunit-containing AMPA glutamate receptors for morphine state-dependency.
Authors: Aitta-Aho Et al.
PLoS One 2012;7:e38325
Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study.
Authors: Lee Et al.
J Cell Biol 2012;63:340
GABAB receptor-positive modulators: brain region-dependent effects.
Authors: Hensler Et al.
J Pharmacol Exp Ther 2012;340:19
Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.
Authors: Ilie Et al.
J Neurosci 2012;32:5321
A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury.
Authors: Park Et al.
Am J Physiol Renal Physiol 2012;303:F721
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
Authors: Stoddart Et al.
Chem Biol 2012;19:1105
Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory.
Authors: Sousa Et al.
Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice.
Authors: Mioranzza Et al.
Prog Neuropsychopharmacol Biol Psychiatry 2011;35:169
Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine.
Authors: Lutz Et al.
Eur Neuropsychopharmacol 2011;21:835
Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
Authors: Yang Et al.
Eur J Immunol 2010;40:449
Role of wake-promoting basal forebrain and adenosinergic mechanisms in sleep-promoting effects of ethanol.
Authors: Thakkar Et al.
Alcohol Clin Exp Res 2010;34:997
Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
Authors: Long Et al.
Proc Natl Acad Sci U S A 2010;335:781
Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
Authors: Burbassi Et al.
Eur J Neurosci 2010;32:1278
Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
Authors: Xi Et al.
J Mol Cell Cardiol 2009;47:684
Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
Authors: Clark Et al.
J Neurosci 2009;29:11237
Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice.
Authors: Yu Et al.
Adenosine A1 and A2a receptors modulate Insemia, glycemia, and lactatemia in fetal sheep.
Authors: Maeda and Koos
Purinergic Signal 2009;296:R693
Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
Authors: Epperson Et al.
Am J Physiol Cell Physiol 2009;296:C1171
Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation.
Authors: Rex Et al.
Am J Respir Crit Care Med 2009;186:85
GTPgammaS incorporation in the rat brain: a study on mu-opioid receptors and CXCR4.
Authors: Burbassi Et al.
J Neuroimmune Pharmacol 2008;3:26
Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.
Authors: Wolk Et al.
Am J Physiol Regul Integr Comp Physiol 2008;178:969
Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives.
Authors: Bhanu Et al.
PLoS One 2008;1782:504
A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.
Authors: Eckle Et al.
J Neurosci 2008;118:3301
Characterization of AMPA receptors targeted by the climbing fiber transmitter mediating presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses.
Authors: Satake Et al.
J Neurosci 2006;26:2278
Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists.
Authors: Rex Et al.
J Neurosci 2005;25:5956
Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
Front Cell Neurosci 2005;25:5502
Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge.
Authors: Kornerup Et al.
Br J Pharmacol 2005;144:1011
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
Authors: Melyan Et al.
J Neurosci 2004;24:4530
Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses.
Authors: Moore Et al.
J Neurosci 2003;100:14397
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This a selective A1 receptor antagonist. We used at 100nM in rat brain slice.